FIGURE

Fig. 5

ID

ZDB-FIG-120327-6

Publication

Friedrich et al., 2012 - Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

The free amino acid profile of que mutants shows elevated levels of BCAAs at 96 hpf. The amino acids are referred to by their three-letter code, except for GABA. Each experiment contained a homogenate of 50 larvae. The error bars indicate standard error. (A) The free amino acid profile for wild-type larvae (n=3). (B) The free amino acid profile of que mutant larvae reveals a dramatic accumulation of BCAAs: isoleucine, leucine and valine. Other amino acid levels were reduced. * Significant difference from wild-type at P<0.05; ** significant difference from wild-type at P<0.01 (n=3). (C) The free amino acid profile of beo, a zebrafish mutant that demonstrates abnormal behavior owing to a CNS defect, indicates that abnormal behavior alone does not markedly alter free amino acid levels (n=1).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dbt^ti274/ti274
Observed In:	branched-chain amino acid metabolic process
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.