FIGURE

Fig. 6

ID

ZDB-FIG-120323-7

Publication

Chen et al., 2011 - Establishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivo

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Fig. 6

The loss of NTR-hKikGR⁺ fluorescent signals in Met-treated killer line correlates with tp53 activity and oxidative stress in skin.

(A–D) Test of tp53-dependency on the loss of NTR-hKikGR⁺ fluorescent signals by tp53 morpholino injection. (E) Statistical comparison of the relative number of NTR-hKikGR⁺ fluorescent signals in tp53 morphants treated with or without Met. (F–K) Test of oxidative status-dependency on the loss of NTR-hKikGR⁺ fluorescent signals by incubation with various concentrations of L-NAC as an anti-oxidant. (L) Statistical comparison of the relative number of NTR-hKikGR⁺ fluorescent signals in killer line embryos treated with Met and/or L-NAC. The cell number is presented as the mean±S.D. Different letters above the error bars indicate significant differences, as tested by one-way ANOVA with Tukey′s pair-wise comparison method. L-NAC, N-acetyl-L-cysteine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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