|ZFIN ID: ZDB-FIG-110221-24|
Fig. 5 mitfa is required at multiple steps in melanocyte development. A) mitfa expression persists at restrictive temperature. Wild-type and mitfafh53 larvae are shown. B) No dct is expressed in neural crest cells when held at restrictive temperature, but retinal expression of dct is not affected. Wild-type, mitfaw2, mitfafh53, and mitfavc7 larvae are shown. Embryos were treated with 0.2 mM PTU to suppress melanin synthesis. All larvae are at the equivalent of 82 h at standard temperature.
|Protruding-mouth||retinal pigmented epithelium||ISH|
|mitfavc7/vc7||heat shock||Protruding-mouth||retinal pigmented epithelium||ISH|
|mitfaw2/w2||heat shock||Protruding-mouth||retinal pigmented epithelium||ISH|
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Reprinted from Developmental Biology, 350(2), Johnson, S.L., Nguyen, A.N., and Lister, J.A., mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell, 405-413, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.