FIGURE

Fig. S4

ID

ZDB-FIG-110218-10

Publication

Barrios et al., 2003 - Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis

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Fig. S4

EphA4 Is Removed from the Basal Cell Membrane during Somite Boundary Formation
(A–F and A′–F′) (A–F) Confocal fluorescence and DIC overlays and (A′–F′) DIC images of EphA4eGFP-expressing cells (green) in the paraxial mesoderm of a (A–C) wild-type and a (D–F) fss^-/- embryo during somite furrow formation. The localization of EphA4eGFP is monitored through time (indicated in minutes at the bottom left). The arrowheads point at the interface between EphA4-expressing cells and nonexpressing cells, where the furrow of de-adhesion is forming and EphA4eGFP protein is being cleared. These observations suggest that Eph/Ephrin signaling may be terminated after boundary formation by the removal of receptor or receptor/ligand signaling complexes in both wild-type intersomitic boundaries and boundaries restored in fss^-/- embryos. The scale bar represents 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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