FIGURE

Fig. 5

ID

ZDB-FIG-110113-11

Publication

Hirota et al., 2010 - High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

Other Figures

Fig. 5

All Figure Page

Back to All Figure Page

Fig. 5

Effect of longdaysin on the circadian period in zebrafish in vivo.

Zebrafish hemizygous for per3-luc were entrained in 12 h light/12 h dark cycles, and then luminescence rhythms were monitored in constant darkness in the presence of various concentrations of longdaysin. Representative luminescence rhythm of individual fish (n = 5 for each condition) was plotted after smoothing with 2.4 h moving average and baseline subtraction with fourth order polynomial curve (A). Period parameter was obtained by curve fitting and plotted against compound concentration (B) (n = 13, 5, 11, and 8 for 0, 1, 3, and 9 μM longdaysin, respectively). Representative pictures of zebrafish after 1 wk of treatment with longdaysin are shown (C). Scale bar, 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.