FIGURE
Fig. 5
- ID
- ZDB-FIG-101105-49
- Publication
- Butler et al., 2010 - Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia
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Fig. 5
Nocodazole-treated embryos lack both EB3-GFP puncta and axonal movement of EB3-GFP. (A) Kymograph of an axon made from a 10-minute time-lapse recording of a neuron from a DMSO-vehicle-treated embryo, demonstrating predominantly anterograde movement of discrete puncta of EB3-GFP fluorescence (n=16). (B) Kymograph of an axon made from a 10-minute time-lapse recording of a neuron from a nocodazole-treated embryo, demonstrating absence of axonal movement of EB3-GFP fluorescence (n=10). Horizontal scale bar: 20 μm, vertical scale bar: 5 minutes. See supplementary material Movies 7 and 8. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Full text @ Dis. Model. Mech.