FIGURE

Fig. 5

ID

ZDB-FIG-101105-49

Publication

Butler et al., 2010 - Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia

Other Figures

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Fig. 5

Nocodazole-treated embryos lack both EB3-GFP puncta and axonal movement of EB3-GFP. (A) Kymograph of an axon made from a 10-minute time-lapse recording of a neuron from a DMSO-vehicle-treated embryo, demonstrating predominantly anterograde movement of discrete puncta of EB3-GFP fluorescence (n=16). (B) Kymograph of an axon made from a 10-minute time-lapse recording of a neuron from a nocodazole-treated embryo, demonstrating absence of axonal movement of EB3-GFP fluorescence (n=10). Horizontal scale bar: 20 μm, vertical scale bar: 5 minutes. See supplementary material Movies 7 and 8.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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