ZFIN ID: ZDB-FIG-101104-34
ErbB2 signaling is essential for cardiac trabeculation in zebrafish. (A,B) Trabeculae start to form in wild-type larvae (A) at 3 dpf but are absent in erbb2 mutants (B). (C,D) The wild-type ventricle (C) is extensively trabeculated at 7 dpf, whereas trabeculae remain absent in erbb2 mutants (D) at the same stage. (E,F) Injection of an antisense morpholino oligonucleotide (MO) designed against erbb2 caused a significant reduction in cardiac trabecular formation (F), whereas a mismatch control MO had no effect (E). (G,H) Cardiac valve formation (arrows) appears to be unaffected in erbb2 mutants (H) compared with wild-type siblings (G).
Gene Expression DetailsNo data available
Antibody Labeling Details No data available
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