header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-FIG-101104-34
Liu et al., 2010 - A dual role for ErbB2 signaling in cardiac trabeculation. Development (Cambridge, England)   137(22):3867-3875 Full text @ Development
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Protruding-mouth to Days 7-13

Fig. 2 ErbB2 signaling is essential for cardiac trabeculation in zebrafish. (A,B) Trabeculae start to form in wild-type larvae (A) at 3 dpf but are absent in erbb2 mutants (B). (C,D) The wild-type ventricle (C) is extensively trabeculated at 7 dpf, whereas trabeculae remain absent in erbb2 mutants (D) at the same stage. (E,F) Injection of an antisense morpholino oligonucleotide (MO) designed against erbb2 caused a significant reduction in cardiac trabecular formation (F), whereas a mismatch control MO had no effect (E). (G,H) Cardiac valve formation (arrows) appears to be unaffected in erbb2 mutants (H) compared with wild-type siblings (G).

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
erbb2st61/st61; s843Tg standard conditions Day 5 atrioventricular valve present, normal
Day 5 heart valve development process quality, normal
erbb2st61/st61; twu26Tg standard conditions Protruding-mouth heart trabecula formation arrested, abnormal
Protruding-mouth myocardium lacks all parts of type trabecular layer, abnormal
Days 7-13 heart trabecula formation arrested, abnormal
Days 7-13 myocardium lacks all parts of type trabecular layer, abnormal
s843Tg; s879Tg + MO1-erbb2 standard conditions Day 5 heart trabecula formation arrested, abnormal
Day 5 myocardium lacks all parts of type trabecular layer, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development