FIGURE

Fig. 10

ID

ZDB-FIG-101025-7

Publication

Larson et al., 2010 - Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation

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Fig. 10

Defects in oligodendrocyte patterning and myelination in puma mutant early larvae. (A–C) sox10:GFP transgene reveals oligodendrocyte cell bodies and processes, that are more disorganized in puma mutants than in wild-type at 5 dpf. Cell bodies are deliberately overexposed (shown here in white) to reveal fainter processes. (A, A′) Low magnification showing the orderly array of myelinating processes in wild-type (arrow), and more disorganized processes in puma mutants. (B, B′) Higher magnification of different individuals. (C, C′) Relatively long processes are observed in both wild-type and puma mutants (arrowheads). Scale bars: in A, 40 μm for A, A′; in 40 μm for B, B′; in C, 40 μm for C, C′.

Expression Data

Gene:	GFP
Fish:	ba4Tg tuba8l3^{j115e1/j115e1}; ba4Tg
Anatomical Terms:	oligodendrocyte cell body oligodendrocyte cell projection
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tuba8l3^{j115e1/j115e1}; ba4Tg
Observed In:	oligodendrocyte cell projection oligodendrocyte differentiation
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 346(2), Larson, T.A., Gordon, T.N., Lau, H.E., and Parichy, D.M., Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation, 296-309, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.