FIGURE

Fig. 6

ID

ZDB-FIG-091214-60

Publication

Rieger et al., 2009 - Cadherin-2 controls directional chain migration of cerebellar granule neurons

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Fig. 6

Migratory pac^-/-R cerebellar GCs show reduced contact stability and adherens junctions.

(A–D) Comparison of contact duration between individual gata1:GFP GCs in time-lapse sequences (white arrowheads) reveals that lack of Cadherin-2 in pac^-/-R GCs significantly reduces the duration of stable cell-cell contacts (E, WT: 95.3±10.9 min versus pac^-/-R: 36.8±5.6 min, n = 29). (F–H) TEM analysis reveals that AJs between pac^-/-R cerebellar neurons are largely absent (G), while numerous AJs are found between individual WT cerebellar neurons (F). (H) pac^-/-R cerebellar neurons appear disorganized (compare with Figure 1J). (I) Quantification of TEM images (3.8±0.9 AJs, n = 10, in WT versus 0.3±0.2 AJs, n = 7, in pac^-/-R-cerebella).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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