Fig. 3

Mutations affecting chondrogenesis. (A) Mutants are shorter and have reduced jaw structures. Wild-type (bottom) and mutant mr hyde²⁰⁵ larva (top) at day 5 of development. The mutant is shorter and has a reduced jaw. Wild-type embryos have an inflated swim bladder. (C) Dorsal view of wild-type day-5 larva. (D) Dorsal view of a day-5 mr hyde²⁰⁵ larva. Notice the rostral position of the eyes and the smaller and bent pectoral fins. (B,E-Q). Ventral views of Alcian blue stained larvae at day 5 of development. (B) Wild-type larva. (E-M) Mutant larvae defective in cartilage formation. Skeletal elements appear smaller and are weakly stained. (E) bulldog⁴⁹⁴, the ceratobranchials are present but smaller; (F) mr hyde^m205; (G) round^m713; (H) crusher^m299; (I) jekyll^m151; (J) zhivago^m315; (K) stumpf^m365; (L) strangelove^m617 and (M) feelgood^m662. N-Q depict mutant larvae that display stunted growth of skeletal elements. (N) apparatchik^m364; (O) rieux^m526 (notice the thicker and shorter ceratohyal) and (P) kimble^m533. (Q) In postdoc^m485 the pharyngeal skeleton is reduced and the ceratohyal is bent ventrally. The pectoral fin is reduced. wt, wild-type; ch, ceratohyal; cb, ceratobranchials; mk, Meckel’s cartilage; pec fin; pectoral fin and qu, quadrate. Scale bars, 100 μm.