ZFIN ID: ZDB-FIG-091113-27
Neuhauss et al., 1996 - Mutations affecting craniofacial development in zebrafish. Development (Cambridge, England)   123:357-367
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 3 Mutations affecting chondrogenesis. (A) Mutants are shorter and have reduced jaw structures. Wild-type (bottom) and mutant mr hyde205 larva (top) at day 5 of development. The mutant is shorter and has a reduced jaw. Wild-type embryos have an inflated swim bladder. (C) Dorsal view of wild-type day-5 larva. (D) Dorsal view of a day-5 mr hyde205 larva. Notice the rostral position of the eyes and the smaller and bent pectoral fins. (B,E-Q). Ventral views of Alcian blue stained larvae at day 5 of development. (B) Wild-type larva. (E-M) Mutant larvae defective in cartilage formation. Skeletal elements appear smaller and are weakly stained. (E) bulldog494, the ceratobranchials are present but smaller; (F) mr hydem205; (G) roundm713; (H) crusherm299; (I) jekyllm151; (J) zhivagom315; (K) stumpfm365; (L) strangelovem617 and (M) feelgoodm662. N-Q depict mutant larvae that display stunted growth of skeletal elements. (N) apparatchikm364; (O) rieuxm526 (notice the thicker and shorter ceratohyal) and (P) kimblem533. (Q) In postdocm485 the pharyngeal skeleton is reduced and the ceratohyal is bent ventrally. The pectoral fin is reduced. wt, wild-type; ch, ceratohyal; cb, ceratobranchials; mk, Meckel’s cartilage; pec fin; pectoral fin and qu, quadrate. Scale bars, 100 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
apam364/m364 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 ceratohyal cartilage decreased length, abnormal
Day 5 ceratohyal cartilage increased thickness, abnormal
Day 5 head decreased length, abnormal
Day 5 palatoquadrate cartilage decreased size, abnormal
Day 5 palatoquadrate cartilage increased thickness, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 quadrate decreased length, abnormal
Day 5 quadrate increased thickness, abnormal
Day 5 whole organism decreased length, abnormal
creb3l2m662/m662 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
hydm205/m205 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 cranial cartilage mislocalised posteriorly, abnormal
Day 5 head decreased length, abnormal
Day 5 mandibular arch skeleton decreased size, abnormal
Day 5 pectoral fin bent, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pectoral fin degenerate, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
kimm533/m533 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 ceratohyal cartilage decreased length, abnormal
Day 5 ceratohyal cartilage increased thickness, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 quadrate decreased length, abnormal
Day 5 quadrate increased thickness, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
posm485/m485 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 ceratohyal cartilage bent, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pectoral fin kinked, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 whole organism decreased length, abnormal
ric1m713/m713 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pectoral fin degenerate, abnormal
Day 5 pectoral fin kinked, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
rixm526/m526 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 ceratohyal cartilage decreased length, abnormal
Day 5 ceratohyal cartilage increased thickness, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 quadrate decreased length, abnormal
Day 5 quadrate increased thickness, abnormal
Day 5 whole organism decreased length, abnormal
sec23am299/m299 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
sec24dm494/m494 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 ceratobranchial cartilage decreased size, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pectoral fin degenerate, abnormal
Day 5 pectoral fin kinked, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
stnm617/m617 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
stp_m365m365/m365 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 whole organism decreased length, abnormal
ugdhm151/m151 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pectoral fin kinked, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
zhim315/m315 (AB) standard conditions Day 5 cartilage development disrupted, abnormal
Day 5 head decreased length, abnormal
Day 5 pectoral fin decreased length, abnormal
Day 5 pharyngeal arch cartilage decreased size, abnormal
Day 5 semicircular canal aplastic, abnormal
Day 5 whole organism decreased length, abnormal
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