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Fig. S2

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ZDB-FIG-091016-11

Publication

Ebarasi et al., 2009 - A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier

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Fig. S2

Tight junctions persist in crb2b MO. (A) Electron micrographs of podocytes from control 4 dpf larvae shows the cell bodies, primary processes (asterisk), and the regular patterned array of foot processes along the GBM; GBM (black arrows). (B, C) In crb2b morphants, podocytes are attached to a GBM (black arrow in C), but the organization of regularly spaced foot processes is lost. Slit diaphragms are absent. Ectopic tight junctions are visible in morphant podocytes (white arrows in B and C). In addition, blunt ended apical membrane projections are found extending into the Bowman′s space (black arrowheads in B and C). A, B 20,000x magnification; C 40,000x magnification.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Biology, 334(1), Ebarasi, L., He, L., Hultenby, K., Takemoto, M., Betsholtz, C., Tryggvason, K., and Majumdar, A., A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier, 1-9, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.