FIGURE

Fig. 5

ID
ZDB-FIG-090504-5
Publication
Serluca et al., 2009 - Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning
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Fig. 5

Pronephric cyst phenotypes in seahorse mutants and sea MO-injected embryos. (A-F) At 2 dpf, the glomerular region (asterisks) appears normal in siblings (A) and seafa20r mutants (B), and slightly dilated in sea MO-injected embryos (C). In the same embryos, the medial tubules (arrows) were significantly dilated both in seafa20r mutants (E) and sea MO-injected embryos (F), compared with siblings (D). (G-L) At 2.5 dpf, the glomeruli (asterisks) in both the seafa20r mutants (H) and sea MO-injected embryos (I) were dilated compared with siblings (G). These same embryos have dilations in the medial tubules (arrows) in seafa20r mutants (K) and sea MO-injected embryos (L) compared with siblings (J). (M-O) At 3 dpf, siblings (M) display basolateral localization of Na+/K+-ATPase (red) in the pronephric epithelium (arrows; white arrowheads indicate lateral staining), whereas the sea mutants (N,O) display altered localization of Na+/K+-ATPase diffusely at apical (yellow arrowheads) and lateral membranes (white arrowheads).

Expression Data
Antibody:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: Protruding-mouth

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Long-pec to Protruding-mouth

Phenotype Detail
Acknowledgments
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