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Fig. 3

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ZDB-FIG-090320-6

Publication

Navratilova et al., 2009 - Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes

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Fig. 3

The genomic locus of PAX6. (A) Ancora view of a 5 Mb window across the human locus (upper track), density of HCNEs compared with the mouse genome (lower track) and conserved synteny in the zebrafish genome. (B) 1 Mb mVISTA plot of human PAX6 compared with zebrafish Xenopus tropicalis, (xt, middle track) and Fugu rubripes (fr, lower track). HCNEs conserved in all four species were tested in zebrafish and are boxed in red. Insets above tracks show two enhancer detection insertions in the pax6a and pax6b genomic regulatory block in zebrafish and the RNA in situ hybridization pattern of these genes in a 2 day zebrafish embryo. Expression is mainly confined to the nervous system (for detailed expression see also Supplementary data).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 327(2), Navratilova, P., Fredman, D., Hawkins, T.A., Turner, K., Lenhard, B., and Becker, T.S., Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes, 526-540, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.