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Fig. 2

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ZDB-FIG-090304-67

Publication

Ochocinska et al., 2009 - NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish

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Fig. 2

Induced neuroD promotes exit from the cell cycle exit in vivo, but does not cause cell death. Panel A illustrates a retina from a wt embryo treated with heat shock at 24hpf and labeled with BrdU and sacrificed at 48hpf. Note the extensive BrdU labeling throughout. Panel B is a retina from a transgenic embryo treated with heat shock at 24hpf and labeled with BrdU and sacrificed at 48hpf. Panel C is the retina illustrated in B, showing the BrdU labeling. Panel D is the digital overlay of panels B and C. Panel E illustrates histograms comparing the number of phosphohistone H3 immunopositive cells in the retinas of wt and transgenic embryos. Panel F illustrates histograms comparing the number of TUNEL-positive cells in the retinas of wt and transgenic embryos. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; CMZ, circumferential marginal zone. Scale bar equals 50 μm.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Mechanisms of Development, 126(3-4), Ochocinska, M.J., and Hitchcock, P.F., NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish, 128-141, Copyright (2009) with permission from Elsevier. Full text @ Mech. Dev.