FIGURE

Fig. 1

ID

ZDB-FIG-080916-10

Publication

Hoptak-Solga et al., 2008 - Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration

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Fig. 1

Growth rate and the number of mitotic cells are reduced in sof^b123 mutants during regeneration. Measurements of regenerates in wild-type and sof^b123 fins were conducted over a period of 9 days. (A) The length of the sof^b123 regenerate is half as long as the wild-type regenerate. Standard deviation is shown. (B) The rate of regeneration is slower in sof^b123 mutants. Standard deviation is shown. (C) The number of mitotic (H3P positive) cells is reduced in sof^b123 mutants compared to wild-type. Standard deviation was calculated and the Student's t-test reveals all data points between wild-type and sof^b123 are statistically different (p = 0.0001; 0.0008; 0.0042; 0.0454 for 1, 3, 7, 9 dpa). (D) The number of mitotic cells per cm is the same between wild-type and sof^b123 fins. Standard deviation was calculated and the Student's t-test reveals data points through 7 dpa are not statistically different (p > 0.06). The data points at 9 dpa are statistically different, p = 0.0001 (*).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gja1b^b123/b123 (C32)
Observed In:	cell population proliferation fin regeneration regenerating fin
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 317(2), Hoptak-Solga, A.D., Nielsen, S., Jain, I., Thummel, R., Hyde, D.R., and Iovine, M.K., Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration, 541-548, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.