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Fig. 4

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ZDB-FIG-080418-3

Publication

Goldsmith et al., 2003 - Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants

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Fig. 4

Independent mesenchymal and epithelial regulation of cell proliferation. Proliferating cells (green), identified by whole-mount BrdU immunohistochemistry, can be seen in both fa93e10-positive (A, B) (purple staining, highlighted by white arrows in A) and fa93e10-negative (C) fins. At higher magnification (B), BrdU-labeled cells in the distal intraray mesenchyme (white arrowheads) are easily identified as they lie in the same focal plane as the actinotrichia (black arrow). (D) Total BrdU-labeled cells in distal fin (mesenchymal and epithelial) were counted for fa93e10-positive (n = 7) and fa93e10-negative (n = 10) fins. (E) fa93e10-positive fins contained significantly more BrdU-labeled cells in the distal intraray mesenchyme than fa93e10-negative fins. (F) To estimate the number of proliferating epithelial cells for fa93e10-positive and fa93e10-negative fins, we subtracted the number of proliferating cells in the intraray mesenchyme (E) from the total number of proliferating cells (D).

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Acknowledgments

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Reprinted from Developmental Biology, 259(2), Goldsmith, M.I., Fisher, S., Waterman, R., and Johnson, S.L., Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants, 303-317, Copyright (2003) with permission from Elsevier. Full text @ Dev. Biol.