FIGURE

Fig. 7

ID

ZDB-FIG-080401-19

Publication

Ignatius et al., 2008 - colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis

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Fig. 7

Genetically reducing foxd3 rescues melanophore development in hdac1^col-/-;foxd3^zdf10+/- mutants. (A–E) Live images with lateral views of 3.5 dpf embryos. Embryos obtained from a heterozygous incross of hdac1^col+/-;foxd3^zdf10+/- carriers gave rise to 4 distinct phenotypes. (A) Wild-type that have melanophores present in 4 distinct stripes: dorsal, lateral, ventral and yolk. (B) foxd3^zdf10 mutants in which the melanophore migration patterns have largely recovered to resemble the wild-type. (C) hdac1^col-/-;foxd3^zdf10+/+ and hdac1^col-/-;foxd3^zdf10+/- mutants whose melanophore phenotype resembles single hdac1^col-/- homozygous mutant phenotype. (D) hdac1^col-/-;foxd3^zdf10-/- double mutants in which there is a reduction in melanophore numbers as well as reduced migration into the lateral, ventral and yolk stripe locations. (E) 10% of phenotypically hdac1^col mutants that are hdac1^col-/-;foxd3^zdf10+/- display a rescue of melanophore number as well as migration into the lateral, ventral and yolk stripes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxd3^zdf10/zdf10 hdac1^b382/b382 hdac1^b382/b382; foxd3^zdf10/+ hdac1^b382/b382; foxd3^zdf10/zdf10
Observed In:	melanocyte melanophore stripe melanophore stripe melanocyte yolk melanophore stripe
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 313(2), Ignatius, M.S., Moose, H.E., El-Hodiri, H.M., and Henion, P.D., colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis, 568-583, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.