FIGURE

Fig. 7

ID

ZDB-FIG-070613-23

Publication

Lowery et al., 2007 - whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish

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Fig. 7

Specific neurons are absent in whitesnake mutants. A-J: Acetylated tubulin antibody labeling (A-F) and HNK-1 antibody labeling (G-J), both of which mark most differentiated neurons and their axons, show reduced number of axons in wis mutant in the hindbrain (B,D,H), midbrain (F), and eyes/forebrain (J) compared with wild-type (A,C,E,G,I). K-N: The RM044 Ab, which labels reticulospinal neurons, shows an absence of all reticulospinal neurons in the wis hindbrain except Mauthner neurons (labeled with M) at both 24 hours postfertilization (hpf, L) and 2 days postfertilization (dpf, N), compared with wild-type (K,M). O-R: The 4D5 Islet antibody, labeling motoneurons, shows no loss of motoneurons in whitesnake in the dorsal diencephalon (P) or spinal cord (R) compared with wild-type (O,Q). A, anterior; P, posterior. A-D,G-P: Dorsal views. E-F,Q-R: Side views. Scale bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sfpq^tr241/tr241
Observed In:	eye axon forebrain axon hindbrain axon hindbrain Mauthner neuron midbrain axon
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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