FIGURE

Fig. 2

ID

ZDB-FIG-060410-22

Publication

von Trotha et al., 2006 - Apical localization of ASIP/PAR-3:EGFP in zebrafish neuroepithelial cells involves the oligomerization domain CR1, the PDZ domains, and the C-terminal portion of the protein

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Fig. 2

The PDZ domains are necessary for the localization of ASIP/PAR-3:EGFP to the apical cortex. A-C: Upon deletion of a single PDZ domain, the corresponding fusion proteins still localize at the apical cortex in essentially the same way as the full-length ASIP/PAR-3:EGFP protein. D: The apical localization is severely impaired upon deletion of all three PDZ domains, although a considerable portion of the fusion protein still localizes to the apical cortex. Apical membrane localization is denoted by arrows. A schematic representation of the different constructs is depicted above the confocal image. Anterior is toward the upper left. Scale bar = 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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