CRISPR

CRISPR1-sigirr

ID

ZDB-CRISPR-250912-1

Name

CRISPR1-sigirr

Previous Names

None

Target

sigirr (1)

Sequence

5' - GGTTGTACTCGCTCTCGCAG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf4276	sigirr

Expression

Gene expression in Wild Types + CRISPR1-sigirr

No data available

Phenotype

Phenotype resulting from CRISPR1-sigirr

No data available

Phenotype of all Fish created by or utilizing CRISPR1-sigirr

Phenotype	Fish	Conditions	Figures
whole organism m17 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine tgfb1a expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestine myd88 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
whole organism traf6 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine muc2.1 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestine acid phosphatase activity increased magnitude, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
whole organism il1b expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine myd88 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestine tgfb1a expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
mid intestine epithelium detached from intestinal lamina propria mucosa, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 6 from Yu et al., 2024
intestinal lamina propria mucosa inflamed, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 6 from Yu et al., 2024
whole organism decreased life span, exacerbated	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine tnfa expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
intestine mmp9 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
defense response to bacterium decreased occurrence, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Mycobacterium marinum	Fig. 1 from Yu et al., 2025
intestine nfkbiaa expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
intestine il10 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
intestine mmp9 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestinal epithelium goblet cell decreased amount, exacerbated	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 7 from Yu et al., 2024
intestine ifng1 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
mid intestine epithelium damaged, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 6 from Yu et al., 2024
intestine il1b expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
intestine lipase activity decreased magnitude, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
whole organism decreased life span, exacerbated	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestine lysozyme activity decreased magnitude, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
intestine il10 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestine traf6 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
spleen increased size, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Mycobacterium marinum	Fig. 1 from Yu et al., 2025
intestine m17 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
whole organism inflammatory response increased occurrence, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Mycobacterium marinum	Fig. 1 from Yu et al., 2025
intestine nfkbiaa expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
whole organism nfkbiaa expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine il1b expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
intestine muc2.1 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
mid intestine intestinal villus structure, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 6 from Yu et al., 2024
whole organism ifng1 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine host-mediated modulation of intestinal microbiota composition process quality, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
whole organism myd88 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
whole organism hemorrhagic, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Mycobacterium marinum	Fig. 1 from Yu et al., 2025
mid intestine intestinal mucosa decreased thickness, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 5 from Yu et al., 2024
defense response to bacterium decreased occurrence, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine tnfa expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
whole organism tnfa expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by exposure to environment: Edwardsiella piscicida	Fig. 1 from Yu et al., 2024
intestine ifng1 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	standard conditions	Fig. 8 from Yu et al., 2024
intestine traf6 expression increased amount, abnormal	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Edwardsiella piscicida	Fig. 3 from Yu et al., 2024
whole organism decreased life span, exacerbated	sigirr^{zf4276/zf4276}	bacterial treatment by injection: Mycobacterium marinum	Fig. 1 from Yu et al., 2025

Citations