CRISPR

CRISPR6-tln1

ID

ZDB-CRISPR-240212-1

Name

CRISPR6-tln1

Previous Names

None

Target

tln1 (1)

Sequence

5' - GGGCGGACGCTGCGGGAGC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
uq1al	tln1

Expression

Gene expression in Wild Types + CRISPR6-tln1

No data available

Phenotype

Phenotype resulting from CRISPR6-tln1

No data available

Phenotype of all Fish created by or utilizing CRISPR6-tln1

Phenotype	Fish	Conditions	Figures
whole organism tln1 expression absent, abnormal	tln1^uq1al/uq1al	standard conditions	Fig. 1 from Chau et al., 2022
cranial vasculature hemorrhagic, abnormal	tln1^uq1al/uq1al	standard conditions	Fig. 1 from Chau et al., 2022
dorsal aorta focal adhesion assembly decreased process quality, abnormal	tln1^uq1al/uq1al; uq2alTg	standard conditions	Fig. 1 from Chau et al., 2022
dorsal aorta cell-cell junction EGFP expression spatial pattern, abnormal	tln1^uq1al/uq1al; uq2alTg	standard conditions	Fig. 1 from Chau et al., 2022
dorsal aorta focal adhesion EGFP expression decreased amount, abnormal	tln1^uq1al/uq1al; uq2alTg	standard conditions	Fig. 1 from Chau et al., 2022
blood vessel endothelial cell focal adhesion assembly decreased process quality, abnormal	tln1^uq1al/uq1al; uq2alTg	standard conditions	Fig. 1 from Chau et al., 2022
blood vessel endothelial cell regulation of actin filament organization process quality, ameliorated	tln1^uq1al/uq1al; uq3alTg	chemical treatment by environment: jaspamide	Fig. 6 from Chau et al., 2022
blood vessel endothelial cell regulation of actin filament organization decreased process quality, abnormal	tln1^uq1al/uq1al; uq3alTg	standard conditions	Fig. 5 , Fig. 6 from Chau et al., 2022
dorsal longitudinal anastomotic vessel vascular plexus decreased branchiness, abnormal	tln1^uq1al/uq1al; uq11bhTg	standard conditions	Fig. 2 from Chau et al., 2022
dorsal aorta cell-cell junction irregularly shaped, abnormal	tln1^uq1al/uq1al; uq11bhTg	control	Fig. 3 , Fig. 6 from Chau et al., 2022
intersegmental vessel angiogenic sprout decreased length, abnormal	tln1^uq1al/uq1al; uq11bhTg	standard conditions	Fig. 2 from Chau et al., 2022
intersegmental vessel dissociated from dorsal longitudinal anastomotic vessel, abnormal	tln1^uq1al/uq1al; uq11bhTg	standard conditions	Fig. 2 from Chau et al., 2022
intersegmental vessel has fewer parts of type intersegmental vessel blood vessel endothelial cell, abnormal	tln1^uq1al/uq1al; uq11bhTg	standard conditions	Fig. 3 from Chau et al., 2022
dorsal aorta blood vessel endothelial cell shape, ameliorated	tln1^uq1al/uq1al; uq11bhTg	chemical treatment by environment: jaspamide	Fig. 6 from Chau et al., 2022
dorsal aorta cell-cell junction shape, ameliorated	tln1^uq1al/uq1al; uq11bhTg	chemical treatment by environment: jaspamide	Fig. 6 from Chau et al., 2022
intersegmental vessel blood vessel endothelial cell shortened, abnormal	tln1^uq1al/uq1al; uq11bhTg	standard conditions	Fig. 3 from Chau et al., 2022
dorsal aorta blood vessel endothelial cell shortened, abnormal	tln1^uq1al/uq1al; uq11bhTg	control	Fig. 3 , Fig. 6 from Chau et al., 2022
intersegmental vessel sprouting angiogenesis decreased process quality, abnormal	tln1^uq1al/uq1al; uq11bhTg	standard conditions	Fig. 2 from Chau et al., 2022
intersegmental vessel regulation of filopodium assembly decreased process quality, abnormal	tln1^uq1al/uq1al; s916Tg	standard conditions	Fig. 2 from Chau et al., 2022
intersegmental vessel sprouting angiogenesis decreased process quality, abnormal	tln1^uq1al/uq1al; s916Tg	standard conditions	Fig. 2 from Chau et al., 2022

Citations