CRISPR

CRISPR1-metrn

ID

ZDB-CRISPR-230919-7

Name

CRISPR1-metrn

Previous Names

None

Target

metrn (1)

Sequence

5' - GGATTTCATTCCTGACGGGT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 24

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
nt200	metrn

Expression

Gene expression in Wild Types + CRISPR1-metrn

No data available

Phenotype

Phenotype resulting from CRISPR1-metrn

No data available

Phenotype of all Fish created by or utilizing CRISPR1-metrn

Phenotype	Fish	Conditions	Figures
heart contraction increased frequency, abnormal	metrn^nt200/+; mi2004Tg	standard conditions	Fig 8 from Kikel-Coury et al., 2021
heart has fewer parts of type heart glial cell (sensu Vertebrata), abnormal	metrn^nt200/nt200; mi2004Tg	chemical treatment by environment: S3I-201	Fig 7 from Kikel-Coury et al., 2021
cardiac ventricle metrn expression decreased amount, abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 6 from Kikel-Coury et al., 2021
heart cardiac glial cell differentiation decreased process quality, abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 7 from Kikel-Coury et al., 2021
cardiac ventricle id1 expression decreased amount, abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 6 from Kikel-Coury et al., 2021
heart neural crest-derived cardiac glial cell differentiation decreased process quality, abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 7 from Kikel-Coury et al., 2021
heart contraction frequency, ameliorated	metrn^nt200/nt200; mi2004Tg	chemical treatment by environment: L-isoprenaline	Fig 9 from Kikel-Coury et al., 2021
heart contraction irregular rhythm, exacerbated	metrn^nt200/nt200; mi2004Tg	chemical treatment by environment: L-isoprenaline	Fig 9 from Kikel-Coury et al., 2021
heart cardiac glial cell differentiation decreased process quality, abnormal	metrn^nt200/nt200; mi2004Tg	chemical treatment by environment: S3I-201	Fig 7 from Kikel-Coury et al., 2021
heart neural crest-derived cardiac glial cell differentiation decreased process quality, abnormal	metrn^nt200/nt200; mi2004Tg	chemical treatment by environment: S3I-201	Fig 7 from Kikel-Coury et al., 2021
cardiac ventricle heart contraction irregular rhythm, abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 8 from Kikel-Coury et al., 2021
heart contraction frequency, ameliorated	metrn^nt200/nt200; mi2004Tg	chemical treatment by environment: carbachol	Fig 9 from Kikel-Coury et al., 2021
cardiac ventricle cdh11 expression decreased amount, abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 6 from Kikel-Coury et al., 2021
heart has fewer parts of type heart glial cell (sensu Vertebrata), abnormal	metrn^nt200/nt200; mi2004Tg	standard conditions	Fig 7 from Kikel-Coury et al., 2021

Citations

Include unpublished citations

Kikel-Coury, N.L., Brandt, J.P., Correia, I.A., O'Dea, M.R., DeSantis, D.F., Sterling, F., Vaughan, K., Ozcebe, G., Zorlutuna, P., Smith, C.J. (2021) Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function. PLoS Biology. 19:e3001444

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