CRISPR

CRISPR1-pdcd11

ID

ZDB-CRISPR-210903-1

Name

CRISPR1-pdcd11

Previous Names

None

Target

pdcd11 (1)

Sequence

5' - GGTCTCCCGAGCGGCCTCGT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf3478	pdcd11

Expression

Gene expression in Wild Types + CRISPR1-pdcd11

No data available

Phenotype

Phenotype resulting from CRISPR1-pdcd11

No data available

Phenotype of all Fish created by or utilizing CRISPR1-pdcd11

Phenotype	Fish	Conditions	Figures
whole organism Ab7-tgfb1 labeling decreased amount, abnormal	pdcd11^{zf3478/zf3478}	chemical treatment by environment: NF-kappaB inhibitor	Fig. 3 from Yang et al., 2020
cranium malformed, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain macrophage increased size, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain microglial cell apoeb expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	chemical treatment by environment: NF-kappaB inhibitor	Fig. 3 from Yang et al., 2020
whole organism il6 expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 , Fig. 3 from Yang et al., 2020
whole organism il1b expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 , Fig. 3 from Yang et al., 2020
brain macrophage lcp1 expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
whole organism tnfa expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 , Fig. 3 from Yang et al., 2020
brain macrophage vacuolated, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain microglial cell csf1b expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 2 from Yang et al., 2020
brain macrophage mfap4.4 expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 , Fig. 3 , Fig. 6 from Yang et al., 2020
brain microglial cell ctsba expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 2 from Yang et al., 2020
whole organism tgfb1a expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 2 from Yang et al., 2020
brain microglial cell csf1ra expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
chordate embryonic development delayed, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain microglial cell absent, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain macrophage increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain il6 expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
yolk syncytial layer tgfb1a expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 2 from Yang et al., 2020
brain macrophage mfap4.4 expression amount, ameliorated	pdcd11^{zf3478/zf3478}	chemical treatment by environment: NF-kappaB inhibitor	Fig. 3 from Yang et al., 2020
whole organism Ab7-tgfb1 labeling decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 3 from Yang et al., 2020
brain microglial cell apoeb expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 , Fig. 3 from Yang et al., 2020
macrophage cxcr3.1 expression increased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
macrophage cxcr3.2 expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
macrophage tnfa expression increased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 1 from Yang et al., 2020
brain macrophage increased size, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 1 from Yang et al., 2020
brain macrophage sall1a expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 2 from Yang et al., 2020
brain macrophage tgfbr1a expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 2 from Yang et al., 2020
brain macrophage vacuolated, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 1 from Yang et al., 2020
brain macrophage ctsl.1 expression increased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 2 from Yang et al., 2020
brain macrophage increased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 1 from Yang et al., 2020
brain macrophage tgfbr1b expression decreased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 2 from Yang et al., 2020
brain macrophage tlr5a expression increased amount, abnormal	pdcd11^{zf3478/zf3478}; gl22Tg	standard conditions	Fig. 2 from Yang et al., 2020
whole organism il6 expression increased amount, abnormal	tp53^zdf1/zdf1; pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
whole organism il1b expression increased amount, abnormal	tp53^zdf1/zdf1; pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
whole organism tnfa expression increased amount, abnormal	tp53^zdf1/zdf1; pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020
brain il6 expression increased amount, abnormal	tp53^zdf1/zdf1; pdcd11^{zf3478/zf3478}	standard conditions	Fig. 1 from Yang et al., 2020

Citations