CRISPR

CRISPR3-cul4b

ID

ZDB-CRISPR-201012-10

Name

CRISPR3-cul4b

Previous Names

c (1)

Target

cul4b (1)

Sequence

5' - GAGGACATTAAGCTGGCCAC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 14

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf3204	cul4b

Expression

Gene expression in Wild Types + CRISPR3-cul4b

No data available

Phenotype

Phenotype resulting from CRISPR3-cul4b

No data available

Phenotype of all Fish created by or utilizing CRISPR3-cul4b

Phenotype	Fish	Conditions	Figures
hematopoietic cell tal1 expression decreased amount, abnormal	cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
hematopoietic cell tal1 expression decreased distribution, abnormal	cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
nucleate erythrocyte decreased amount, abnormal	cul4b^{zf3204/zf3204}	standard conditions	Fig. 1 from Yang et al., 2019
hematopoietic cell lmo2 expression decreased amount, abnormal	cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
hematopoietic cell lmo2 expression decreased distribution, abnormal	cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
hematopoietic cell tal1 expression decreased distribution, abnormal	cul4a^{zf3203/zf3203}; cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
hematopoietic cell lmo2 expression decreased amount, abnormal	cul4a^{zf3203/zf3203}; cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
nucleate erythrocyte hemoglobin complex hbbe3 expression decreased distribution, abnormal	cul4a^{zf3203/zf3203}; cul4b^{zf3204/zf3204}	standard conditions	Fig. 1 from Yang et al., 2019
hematopoietic cell lmo2 expression decreased distribution, abnormal	cul4a^{zf3203/zf3203}; cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
hematopoietic cell tal1 expression decreased amount, abnormal	cul4a^{zf3203/zf3203}; cul4b^{zf3204/zf3204}	standard conditions	Fig. 4 from Yang et al., 2019
nucleate erythrocyte absent, abnormal	cul4a^{zf3203/zf3203}; cul4b^{zf3204/zf3204}	standard conditions	Fig. 1 from Yang et al., 2019

Citations

Include unpublished citations

Yang, F., Hu, H., Liu, Y., Shao, M., Shao, C., Gong, Y. (2019) Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death & Disease. 10:388

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