ZFIN CRISPR: CRISPR3-vtg

Target Location

Genome Build: GRCz11Chromosome: 7

Genome Build: GRCz11Chromosome: 13

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
inr101	vtg1

Expression

Gene expression in Wild Types + CRISPR3-vtg

No data available

Phenotype

Phenotype resulting from CRISPR3-vtg

No data available

Phenotype of all Fish created by or utilizing CRISPR3-vtg

Phenotype	Fish	Conditions	Figures
yolk edematous, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 9 from Yilmaz et al., 2019
female organism unfertilized egg vtg5 expression absent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 5 from Yilmaz et al., 2019
female organism liver vtg7 expression increased amount, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 4, Fig. 5 from Yilmaz et al., 2019
female organism unfertilized egg vtg1 expression absent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 5 from Yilmaz et al., 2019
fertilized egg hatching decreased rate of occurrence, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 7 from Yilmaz et al., 2019
female organism liver vtg5 expression absent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 4, Fig. 5 from Yilmaz et al., 2019
whole organism decreased life span, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 8 from Yilmaz et al., 2019
female organism unfertilized egg vtg7 expression increased amount, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 5 from Yilmaz et al., 2019
post-vent region bent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 9 from Yilmaz et al., 2019
female organism unfertilized egg vtg4 expression absent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 5 from Yilmaz et al., 2019
post-vent region curved, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 9 from Yilmaz et al., 2019
whole organism dead, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 8 from Yilmaz et al., 2019
female organism unfertilized egg vtg3 expression increased amount, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 5 from Yilmaz et al., 2019
pericardium edematous, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 9 from Yilmaz et al., 2019
female organism oocyte increased amount, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 7 from Yilmaz et al., 2019
female organism liver vtg1 expression absent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 4, Fig. 5 from Yilmaz et al., 2019
female organism liver vtg4 expression absent, abnormal	vtg1^{inr101/inr101} (TU)	standard conditions	Fig. 4, Fig. 5 from Yilmaz et al., 2019
female organism liver vtg4 expression decreased amount, abnormal	vtg1^inr101/+ (TU)	standard conditions	Fig. 4 from Yilmaz et al., 2019
female organism liver vtg1 expression decreased amount, abnormal	vtg1^inr101/+ (TU)	standard conditions	Fig. 4 from Yilmaz et al., 2019

Citations

Include unpublished citations

Yilmaz, O., Patinote, A., Com, E., Pineau, C., Bobe, J. (2021) Knock out of specific maternal vitellogenins in zebrafish (Danio rerio) evokes vital changes in egg proteomic profiles that resemble the phenotype of poor quality eggs. BMC Genomics. 22:308
Yilmaz, O., Patinote, A., Nguyen, T., Com, E., Pineau, C., Bobe, J. (2019) Genome editing reveals reproductive and developmental dependencies on specific types of vitellogenin in zebrafish (Danio rerio). Molecular reproduction and development. 86(9):1168-1188

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