Gene
vtg6
- ID
- ZDB-GENE-001201-5
- Name
- vitellogenin 6
- Symbol
- vtg6 Nomenclature History
- Previous Names
-
- vg6
- si:rp71-23d18.1
- wu:fb62e09
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable lipid transporter activity. Predicted to be involved in cellular response to estrogen stimulus and response to estradiol. Predicted to act upstream of or within lipid transport. Is expressed in female organism; intestine; liver; ovary; and unfertilized egg.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vtg | (2) | |
| CRISPR2-vtg | (2) | |
| CRISPR3-vtg | (2) |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR015255 | Vitellinogen, open beta-sheet |
| Domain | IPR015258 | Vitellinogen, beta-sheet shell |
| Family | IPR050733 | Vitellogenin/Apolipophorin |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
| Homologous_superfamily | IPR015817 | Vitellinogen, open beta-sheet, subdomain 1 |
| Homologous_superfamily | IPR015819 | Lipid transport protein, beta-sheet shell |
| Homologous_superfamily | IPR037088 | Vitellinogen, beta-sheet shell domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, beta-sheet shell | Vitellinogen, beta-sheet shell domain superfamily | Vitellinogen, open beta-sheet | Vitellinogen, open beta-sheet, subdomain 1 | Vitellogenin/Apolipophorin | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NG90 | InterPro | 1374 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-23D18 | ZFIN Curated Data | |
| Encodes | EST | fb62e09 | ||
| Encodes | cDNA | MGC:173433 | ZFIN Curated Data | |
| Has Artifact | EST | fb63b01 |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122610 (1) | 4244 nt | ||
| Genomic | GenBank:BX248330 (1) | 189880 nt | ||
| Polypeptide | UniProtKB:A0A8M1NG90 (1) | 1374 aa |
No data available
- Liu, Z., Zhang, N., Wang, C., Shi, L., Hu, Y., Wang, Y., Li, J. (2024) Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish†. Biology of reproduction. 111(1):123-134
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Yilmaz, O., Com, E., Pineau, C., Bobe, J. (2023) Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio). Scientific Reports. 13:1879518795
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Yilmaz, O., Patinote, A., Com, E., Pineau, C., Bobe, J. (2021) Knock out of specific maternal vitellogenins in zebrafish (Danio rerio) evokes vital changes in egg proteomic profiles that resemble the phenotype of poor quality eggs. BMC Genomics. 22:308
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Maradonna, F., Gioacchini, G., Notarstefano, V., Fontana, C.M., Citton, F., Dalla Valle, L., Giorgini, E., Carnevali, O. (2020) Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish. International Journal of Molecular Sciences. 21(23):
1 - 10 of 43
Show