ZFIN CRISPR: CRISPR1-psen2

Target Location

Genome Build: GRCz11Chromosome: 1

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
ia52	psen2
uaa7	psen2
uaa8	psen2

Expression

Gene expression in Wild Types + CRISPR1-psen2

No data available

Phenotype

Phenotype resulting from CRISPR1-psen2

No data available

Phenotype of all Fish created by or utilizing CRISPR1-psen2

Phenotype	Fish	Conditions	Figures
whole organism Ab9-map1lc3b labeling increased amount, abnormal	psen2^ia52/ia52	food availability	Figure 6 from Barazzuol et al., 2023
startle response increased process quality, abnormal	psen2^ia52/ia52	control	Figure 3 from Barazzuol et al., 2023
brain Ab9-map1lc3b labeling increased amount, abnormal	psen2^ia52/ia52	standard conditions	Figure 6 from Barazzuol et al., 2023
integument decreased pigmentation, abnormal	psen2^ia52/ia52	standard conditions	Figure 1 from Barazzuol et al., 2023
brain psen2 expression decreased amount, abnormal	psen2^ia52/ia52	standard conditions	Figure 1 from Barazzuol et al., 2023
whole organism autophagy increased process quality, abnormal	psen2^ia52/ia52	control	Figure 6 from Barazzuol et al., 2023
whole organism Ab9-map1lc3b labeling increased amount, abnormal	psen2^ia52/ia52	control	Figure 6 from Barazzuol et al., 2023
whole organism Ab9-map1lc3b labeling increased amount, abnormal	psen2^ia52/ia52	chemical treatment by environment: bafilomycin A1, food availability	Figure 6 from Barazzuol et al., 2023
melanophore stripe melanin biosynthetic process decreased process quality, abnormal	psen2^ia52/ia52	standard conditions	Figure 1 from Barazzuol et al., 2023
whole organism Ab9-map1lc3b labeling increased amount, abnormal	psen2^ia52/ia52	chemical treatment by environment: sirolimus, chemical treatment by environment: bafilomycin A1	Figure 6 from Barazzuol et al., 2023
brain autophagy increased process quality, abnormal	psen2^ia52/ia52	standard conditions	Figure 6 from Barazzuol et al., 2023
whole organism Ab9-map1lc3b labeling increased amount, abnormal	psen2^ia52/ia52	chemical treatment by environment: bafilomycin A1	Figure 6 from Barazzuol et al., 2023
melanophore stripe melanocyte decreased pigmentation, abnormal	psen2^uaa7/uaa7	standard conditions	Fig 1 from Jiang et al., 2020 Fig. 5 from Jiang et al., 2018
melanophore stripe melanocyte decreased pigmentation, abnormal	psen2^uaa8/uaa8	standard conditions	Fig. 5 from Jiang et al., 2018

Citations

Include unpublished citations

Barazzuol, L., Cieri, D., Facchinello, N., Calì, T., Washbourne, P., Argenton, F., Pizzo, P. (2023) Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis. Cells. 12(3):
Jiang, H., Newman, M., Lardelli, M. (2018) The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. PLoS One. 13:e0206155

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