CRISPR

CRISPR1-abcc9

ID

ZDB-CRISPR-190304-3

Name

CRISPR1-abcc9

Previous Names

Abcc9_p.G989E (1)

Target

abcc9 (1)

Sequence

5' - GACCATGAGGAAGCCGCCTG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 4

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
hu11838	abcc9

Expression

Gene expression in Wild Types + CRISPR1-abcc9

No data available

Phenotype

Phenotype resulting from CRISPR1-abcc9

No data available

Phenotype of all Fish created by or utilizing CRISPR1-abcc9

Phenotype	Fish	Conditions	Figures
ventricular myocardium ATP-activated inward rectifier potassium channel activity decreased occurrence, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 6 from Smeland et al., 2019
heart process process quality, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. S10 from Tessadori et al., 2018
cardiac muscle cell ATP-activated inward rectifier potassium channel activity decreased occurrence, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 6 from Smeland et al., 2019
cardiac ventricle malformed, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 7 from Smeland et al., 2019
heart contraction decreased magnitude, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 7 from Smeland et al., 2019
atrium apoptotic process increased occurrence, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 7 from Smeland et al., 2019
cardiac ventricle increased size, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 7 from Smeland et al., 2019
pericardium edematous, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. S10 from Tessadori et al., 2018
eye decreased distance eye, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 6 from Smeland et al., 2019
cardiac ventricle apoptotic process increased occurrence, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 7 from Smeland et al., 2019
swimming decreased process quality, abnormal	abcc9^{hu11838/hu11838}	standard conditions	Fig. 6 from Smeland et al., 2019
eye increased distance eye, abnormal	abcc9^{hu11838/hu11838} (TL)	control	Figure 4 from Efthymiou et al., 2024
eye decreased diameter, abnormal	abcc9^{hu11838/hu11838} (TL)	control	Figure 4 from Efthymiou et al., 2024
swimming behavior process quality, abnormal	abcc9^{hu11838/hu11838} (TL)	control	Figure 4 from Efthymiou et al., 2024
whole organism decreased length, abnormal	abcc9^{hu11838/hu11838} (TL)	control	Figure 4 from Efthymiou et al., 2024
swimming behavior increased process quality, exacerbated	abcc9^{hu11838/hu11838} (TL)	chemical treatment by environment: pentetrazol	Figure 4 from Efthymiou et al., 2024
heart process process quality, abnormal	abcc9^hu11838/+	standard conditions	Fig. S10 from Tessadori et al., 2018
pericardium edematous, abnormal	abcc9^hu11838/+	standard conditions	Fig. S10 from Tessadori et al., 2018
regulation of potassium:proton exchanging ATPase activity decreased process quality, abnormal	abcc9^{hu11838/hu11838}; p151Tg/p151Tg	primary cell culture: atrial myocardium	Fig. 5 from Singareddy et al., 2021
regulation of potassium:proton exchanging ATPase activity decreased process quality, abnormal	abcc9^{hu11838/hu11838}; p151Tg/p151Tg	primary cell culture: ventricular myocardium	Fig. 4 from Singareddy et al., 2021

Citations

Include unpublished citations

Tessadori, F., Roessler, H.I., Savelberg, S.M.C., Chocron, S., Kamel, S.M., Duran, K.J., van Haelst, M.M., van Haaften, G., Bakkers, J. (2018) Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Disease models & mechanisms. 11(10):

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