CRISPR
CRISPR1-hdac1
Target Location
Constructs
No data available
Genomic Features
Expression
Gene expression in Wild Types + CRISPR1-hdac1
No data available
Phenotype
Phenotype resulting from CRISPR1-hdac1
| Phenotype | Fish | Figures |
|---|---|---|
| brain structure, abnormal | kca66Tg + CRISPR1-hdac1 |
Fig. 6 
from Schultz et al., 2018 |
| optic tectum decreased size, abnormal | kca66Tg + CRISPR1-hdac1 |
Fig. 6
from Schultz et al., 2018 |
Phenotype of all Fish created by or utilizing CRISPR1-hdac1
| Phenotype | Fish | Conditions | Figures |
|---|---|---|---|
| retina structure, abnormal | hdac1is70/is70 | control |
Fig. 5
from Schultz et al., 2018 |
| brain decreased size, abnormal | hdac1is70/is70 | control |
Fig. 5
from Schultz et al., 2018 |
| trunk curved, abnormal | hdac1is70/is70 | control |
Fig. 5
from Schultz et al., 2018 |
| whole organism decreased size, abnormal | hdac1is70/is70 | control |
Fig. 5
from Schultz et al., 2018 |
| optic tectum decreased size, abnormal | kca6Tg + CRISPR1-hdac1 | control |
Fig. 6
from Schultz et al., 2018 |
| brain structure, abnormal | kca6Tg + CRISPR1-hdac1 | control |
Fig. 6
from Schultz et al., 2018 |
| brain structure, abnormal | kca66Tg + CRISPR1-hdac1 | control |
Fig. 6
from Schultz et al., 2018 |
| optic tectum decreased size, abnormal | kca66Tg + CRISPR1-hdac1 | control |
Fig. 6
from Schultz et al., 2018 |
Citations
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Schultz, L.E., Haltom, J.A., Almeida, M.P., Wierson, W.A., Solin, S.L., Weiss, T.J., Helmer, J.A., Sandquist, E.J., Shive, H.R., McGrail, M. (2018) Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation. Disease models & mechanisms. 11(6)
1 - 2 of 2
Show