ZFIN CRISPR: CRISPR2-wnt9a

Target Location

Genome Build: GRCz11Chromosome: 2

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf754	wnt9a
zf758	wnt9a

Expression

Gene expression in Wild Types + CRISPR2-wnt9a

No data available

Phenotype

Phenotype resulting from CRISPR2-wnt9a

No data available

Phenotype of all Fish created by or utilizing CRISPR2-wnt9a

Phenotype	Fish	Conditions	Figures
interhyal cartilage chondrocyte decreased amount, abnormal	wnt9a^zf754/zf754	standard conditions	Fig. 5 from Ling et al., 2017
Meckel's cartilage shortened, abnormal	wnt9a^zf754/zf754	standard conditions	Fig. 2 from Ling et al., 2017
quadrate-anguloarticular joint morphology, abnormal	wnt9a^zf754/zf754	standard conditions	Fig. 5 from Ling et al., 2017
palate chondrocyte size, abnormal	wnt9a^zf758/zf758	standard conditions	Fig. 2 from Rochard et al., 2016
palate decreased width, abnormal	wnt9a^zf758/zf758	standard conditions	Fig. 1 from Rochard et al., 2016
palate increased length, abnormal	wnt9a^zf758/zf758	standard conditions	Fig. 1 from Rochard et al., 2016
ossification process quality, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 4 from Ling et al., 2017
endochondral bone absent, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 4 from Ling et al., 2017
Meckel's cartilage chondrocyte positional polarity, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 3 from Ling et al., 2017
head muscle decreased length, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 5 from Ling et al., 2017
chondrocyte microtubule organizing center disorganized, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 3 from Ling et al., 2017
Meckel's cartilage chondrocyte morphology, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 3 from Ling et al., 2017
ceratobranchial 5 bone absent, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 4 from Ling et al., 2017
retroarticular absent, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 4 from Ling et al., 2017
endochondral ossification disrupted, abnormal	wnt9a^zf754/zf754; ir937Tg	standard conditions	Fig. 4 from Ling et al., 2017
palate chondrocyte size, abnormal	wls^zf759/zf759; wnt9a^zf758/zf758	standard conditions	Fig. 4 from Rochard et al., 2016
palate decreased width, abnormal	wls^zf759/zf759; wnt9a^zf758/zf758	standard conditions	Fig. 4 from Rochard et al., 2016
palate chondrocyte irregular spatial pattern, abnormal	wls^zf759/zf759; wnt9a^zf758/zf758	standard conditions	Fig. 4 from Rochard et al., 2016
palate chondrocyte size, abnormal	wnt9a^zf758/zf758; wnt5b^{hi2735bTg/hi2735bTg}	standard conditions	Fig. 4 from Rochard et al., 2016
palate decreased width, abnormal	wnt9a^zf758/zf758; wnt5b^{hi2735bTg/hi2735bTg}	standard conditions	Fig. 4 from Rochard et al., 2016

Citations

Include unpublished citations

Ling, I.T., Rochard, L., Liao, E.C. (2017) Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification. Developmental Biology. 421(2):219-232
Rochard, L., Monica, S.D., Ling, I.T., Kong, Y., Roberson, S., Harland, R., Halpern, M., Liao, E.C. (2016) Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis. Development (Cambridge, England). 143:2541-7

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