Genomic Feature
m806
- ID
- ZDB-ALT-980520-19
- Name
- m806
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 15: 20386193 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Val>Asp at position 1012 (1)
- Flanking Sequence
-
ATAGTCCCATGACTCCTGGCGCTCCGTCTCCTGGGGGTTACAACCCTCACACCCCTGGCTCCAACATTGACCAAGCCTCCAATGACTGGGTCACCACAGACATCATGGTGCGTGTGAAAGACACATTCCTTGATGGAGGCGTCATCAATCAGACCGGCATCATCCGCAGTGTCACCGTGAGTCAAGTTTTGAATCTTGTTCATGTGGACATTTATCAGATTCTTTTGGCTACTTAGATTACTTTATGACGGCCAACTGGAATATGCAAATTCATAAACCGCATGTTTCTGCTTGCAGACTCTAGCAGATAATAGTAAACACCCCAGTTTTATGGCTCAGTTTTAGATTTGGCAACTGAGACACTGGTGAACCTTTGATTGATTGATTAAGTGGCTCTTAAAGCCTTTTATTATTAGACGTCACTGCTACATGCTTGTGACGTCTGAAAAAAAATCAACAACTTAATCCTGGTACTTTTTCACAGGGAGGAATGTGCTCTG
T/A TTTTCTGCAAGACACTGAAAAGGTTGTTAGCATTTCAAGCGAACACTTGGAGCCTGTTACACCAACCAAAAACAATAAGGTACTGATATGTTTATGGAAATTCAAGTTTTTGAGTTATTGCAATTATGTTTATGGTTTTTTTATCGCAAGGTCTTGTGTAATCTCAAGGTGATATCGTCTTGCAGGTGTCCTGTTGTTTTTCAGTTTCTTTCCTTTTCTTAGAGGTGCACAATTCTAAATACAGAATATTTTTATTAAAATTCTCTTATAATTATGAATAGACAGCTAGAAGCATATTTGGTAACACTTTATAATGACTGCCAACTATGAGCCATTTTTTAAGCATTAGCAAATAGTTAATTCATTATCTCTTAAGCATTAACTCTACATTAATAAAGGTAAGTAAGCAGTTACAAATGCTGTATTCTTGACTTATAACCACATTTAAATTCTGCTTAATAATTATACAATCATAATTTGTTGAAAATGTATTTTTCATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| supt5hm806/m806 | Homozygous | Unknown | 2 figures  from 2 publications | 3 figures from 2 publications | |
| supt5hm806/m806 | Homozygous | ♀+/- ♂+/- | 5 figures from 2 publications | 4 figures from Yang et al., 2016 | |
| supt5hm806/+ | Heterozygous | Unknown | |||
| supt5hm806/m806; la2Tg | Complex | 2 figures from Yang et al., 2016 | 3 figures from Yang et al., 2016 | ||
| supt5hm806/m806; la2Tg; la401Tg | Complex | 2 figures from Yang et al., 2016 | 2 figures from Yang et al., 2016 | ||
| supt5hm806/m806; y1Tg | Complex | Fig. 4 from Yang et al., 2016 | |||
| supt5hm806/m806 + MO14-cdk9 | Complex | Fig. 3 from Yang et al., 2016 | |||
| supt5hm806/m806; trim33tg234/tg234 | Complex | Fig. 5 from Bai et al., 2010 | Fig. 5 from Bai et al., 2010 |
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Supplemental Information
- Genotyping protocol
- None
- Yang, Q., Liu, X., Zhou, T., Cook, J., Nguyen, K., Bai, X. (2016) RNA polymerase II pausing differentially regulates signaling pathway genes to control hematopoietic stem cell emergence in zebrafish. Blood. 128(13):1701-10
- White, R.M., Cech, J., Ratanasirintrawoot, S., Lin, C.Y., Rahl, P.B., Burke, C.J., Langdon, E., Tomlinson, M.L., Mosher, J., Kaufman, C., Chen, F., Long, H.K., Kramer, M., Datta, S., Neuberg, D., Granter, S., Young, R.A., Morrison, .S, Wheeler, G.N., and Zon, L.I. (2011) DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 471(7339):518-522
- Bai, X., Kim, J., Yang, Z., Jurynec, M.J., Akie, T.E., Lee, J., LeBlanc, J., Sessa, A., Jiang, H., DiBiase, A., Zhou, Y., Grunwald, D.J., Lin, S., Cantor, A.B., Orkin, S.H., and Zon, L.I. (2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142(1):133-143
- Krishnan, K., Salomonis, N., and Guo, S. (2008) Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 3(11):e3621
- Cooper, K.L., Armstrong, J., and Moens, C.B. (2005) Zebrafish foggy/spt5 is required for migration of facial branchiomotor neurons but not for their survival. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(3):651-658
- Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H., and Rosenthal, A. (2000) A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 408(6810):366-369
- Malicki, J. (2000) Harnessing the power of forward genetics – analysis of neuronal diversity and patterning in the zebrafish retina. Trends in neurosciences. 23(11):531-541
- Guo, S., Wilson, S.W., Cooke, S., Chitnis, A.B., Driever, W., and Rosenthal, A. (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Developmental Biology. 208:473-487
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