Genomic Feature
tp49d
- ID
- ZDB-ALT-980413-466
- Name
- tp49d
- Synonyms
-
- P49D (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 45623339 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Arg>Stop at position 195 (1)
- Flanking Sequence
-
TTTCCGCGCCTACTTGTGGCTTCTTTTGCGCTCCTCAGAAACTATGGGTGACGTCACAGACACTACGTCTATATATTTTACAGTCTATGGTTTATACCTGCCAACACTCCCATTTTTCCCCGGAGTCTCCCATATTTCAGACCCATCTCCCGTTTCGGTCTGACTCACGGAAAACTCCCGGAATATCACCCCGTAAAACCCCACCCCCCACTCCACCTCCAATGATTTCATTTGTGCTTTAAAAGCATATTCTAAAAATAAACAGATGGTTATCATTTGTCTGTGTGGAGATTAATATATTAACATTAAATCTATTCATATTTATGGTTATCGTACTTGGTGTAAATGGCTATATATTATTAACTGTTTGTTTATTAAAGTTTGTCTTGTCTGTTTTCCAGGAGAGGAAGGGCATCAAGGAGAGCAGTGGGAGTCGAGAACAGAAAGATCCAGATCAACCCAAAGATCAAGAGAGCAAGAGGGACGACAAGGACCGCAGA
C/T GAGATGCTGAGAGGTCTGACAAAGGCCGAGAAAGAGAGCGAACAAAAGACAGAGATCGAGACAAGGACAAGAGCCGCGATCGGGAGAAAGACAAGACTCGAGAGAAAGAGCGGGAACGAGAGAAGGATCGTAACAGAGAGAAGGAGAGAGAGCGGGATAAAGATCGAGATAAGAAGAAGGAGAGGGAATCTCACAAAGACAGAGAACGGGACAAAGATCGTGAGCGCGAGAAACGGCGGGAGAAAGAGAAGGACAAAGAAAGACCCAGAGAGACTGAGGAGAAACTAAAAGACAGAGGCGACAGAAAGGTTGGTTCGCTCTGCTTTATGACTCTGACACATACTTTAAATTATTCATTTCAAACCTCATTCTGACCCTTTCCCTGAAATTATTCACTACGAAAACACATCGGTTTCACAAAAACATTCATATATTTCAGAAATATTTATTTTATTTTACTTTTTTTATTTAAAGAACAGCATATAACATTTTACAATAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| traf3ip1tp49d/tp49d | Homozygous | ♀+/- ♂+/- | 23 figures  from 10 publications | Fig. S6 from Omori et al., 2008 | |
| traf3ip1tp49d/tp49d (AB) | Homozygous | ♀+/- ♂+/- | 3 figures from Stawicki et al., 2016 | ||
| traf3ip1tp49d/+ (AB) | Heterozygous | Unknown | |||
| traf3ip1tp49d | Unknown | Unknown | Fig. for (tp49d) from Phenotype Annotation (1994-2006) | ||
| traf3ip1tp49d/tp49d; jf7Tg | Complex | 3 figures from D'Gama et al., 2024 | Figure 5 from D'Gama et al., 2024 | ||
| traf3ip1tp49d/tp49d; nns9Tg | Complex | Figure 3 from D'Gama et al., 2024 | Figure 3 from D'Gama et al., 2024 | ||
| kif3asa1617/sa1617; traf3ip1tp49d/tp49d | Complex | 2 figures from Pooranachandran et al., 2016 | |||
| traf3ip1tp49d/tp49d + MO1-map4l | Complex | Fig. 7 from Bizet et al., 2015 | |||
| mitfaw2/w2; traf3ip1tp49d/tp49d | Complex | 2 figures from Elworthy et al., 2019 | |||
| mitfaw2/w2; traf3ip1tp49d/tp49d; s898Tg/+; sh441Tg/+; sh488Tg/+ | Complex | Fig. 12 from Elworthy et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- D'Gama, P.P., Jeong, I., Nygård, A.M., Trinh, A.T., Yaksi, E., Jurisch-Yaksi, N. (2024) Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish. iScience. 27:110078110078
- Peralta, M., Ortiz Lopez, L., Jerabkova, K., Lucchesi, T., Vitre, B., Han, D., Guillemot, L., Dingare, C., Sumara, I., Mercader, N., Lecaudey, V., Delaval, B., Meilhac, S.M., Vermot, J. (2020) Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis. Cell Reports. 32:107932
- Thouvenin, O., Keiser, L., Cantaut-Belarif, Y., Carbo-Tano, M., Verweij, F., Jurisch-Yaksi, N., Bardet, P.L., van Niel, G., Gallaire, F., Wyart, C. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. 9:
- Elworthy, S., Savage, A.M., Wilkinson, R.N., Malicki, J.J., Chico, T.J.A. (2019) The role of endothelial cilia in post-embryonic vascular development. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(6):410-425
- Cantaut-Belarif, Y., Sternberg, J.R., Thouvenin, O., Wyart, C., Bardet, P.L. (2018) The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis. Current biology : CB. 28(15):2479-2486.e4
- Olstad, E.W., Ringers, C., Hansen, J.N., Wens, A., Brandt, C., Wachten, D., Yaksi, E., Jurisch-Yaksi, N. (2018) Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development. Current biology : CB. 29(2):229-241.e6
- Pooranachandran, N., Malicki, J.J. (2016) Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics. 203(2):771-85
- Stawicki, T.M., Hernandez, L., Esterberg, R., Linbo, T., Owens, K.N., Shah, A.N., Thapa, N., Roberts, B., Moens, C.B., Rubel, E.W., Raible, D.W. (2016) Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish. G3 (Bethesda). 6(7):2225-35
- Bizet, A.A., Becker-Heck, A., Ryan, R., Weber, K., Filhol, E., Krug, P., Halbritter, J., Delous, M., Lasbennes, M.C., Linghu, B., Oakeley, E.J., Zarhrate, M., Nitschké, P., Garfa-Traore, M., Serluca, F., Yang, F., Bouwmeester, T., Pinson, L., Cassuto, E., Dubot, P., Elshakhs, N.A., Sahel, J.A., Salomon, R., Drummond, I.A., Gubler, M.C., Antignac, C., Chibout, S., Szustakowski, J.D., Hildebrandt, F., Lorentzen, E., Sailer, A.W., Benmerah, A., Saint-Mezard, P., Saunier, S. (2015) Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nature communications. 6:8666
- Jin, D., Ni, T.T., Sun, J., Wan, H., Amack, J.D., Yu, G., Fleming, J., Chiang, C., Li, W., Papierniak, A., Cheepala, S., Conseil, G., Cole, S.P., Zhou, B., Drummond, I.A., Schuetz, J.D., Malicki, J., Zhong, T.P. (2014) Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nature cell biology. 16(9):841-51
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