Genomic Feature
m294
- ID
- ZDB-ALT-980203-609
- Name
- m294
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 12: 48211856 (GRCz11) (1) Details
- Nucleotide change
- T/C
- Variant Notes
-
A mutation in the second cysteine of the mature ligand region.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Arg (1)
- Flanking Sequence
-
TCCAGAATAGACCCCGGAGACCATCAGCAGCCCCTAAAGGACAGGAGCTCCAGAGCAGGCCCAGCAGACCAGCGACAGCTCCTAGGGGACAGGAGCTCCAGAGCGCACCCCAGCGGCCAGTAGTGGCCCCTGGGGGTCGGGAGATTCATAGCAGGCCCTGGTTGCCAGCAGCAACCCCTGGGGGACAGGAGATCCAGAATGGGACCCAGAAACACAGAGCCATGCTGCTGCTGTTTTCAGAGCAGCAGGACGGGGCCAGTCTCCTACACACCGCCGGGGCCTCGAAGTTTCTGTTTTCTAGAAATAAGAAAGAAGTCAAGCGAGGACGGGCCCTCAGGAGCCGCAGGGGCCGCCGGGGGCCACCTGTCAGGAGCCCAGAGCTGCAGAGAACACCACTGCACAAGAGCACCACCTGCAGGAGGGTGGACATGCATGTGGATTTTAACCAGATCGGATGGGGCTCCTGGATCGTGTTCCCTAAGAAGTACAATGCATACCGG
T/C GCGAGGGGGCCTGCCCGAACCCACTGGGAGAAGAGCTGCGGCCCACCAATCATGCATACATGCAGGTACTACGGTATATGTGTAAATATAACTTTAAATACATGGATAAATGTGTAAATGTTAATTATTTTAAATTAATCTGGCTTTCAATAAAATATAAGCTAATTAGCATTTTTAAAAGTAGATTTAAATAGTTTAAAATATTTATATTAAATATTTTGTAATGGCATAAAAATAGGTAGATAAGAATATAAATAATAATTGTTTGAAATAAAAGTTGCTTTAATTTAAATTTATATTAATTAGCATTTTTAACTGATGTGAAAAATTAAAGCTCAAAAATATTTATAATAAAACAACATAAATAAATGTAGAAATATTAAATAAAATGTAATTTCAAATAAATCTAAAACTATAAAACTAAAACTAATACAAGATTGTGTTACTATAATGTTATACAATTTATAGATAAGCATAAATTTATAAAATAAAAATTTATA - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
ndr2m294/m294 | Homozygous | ♀+/- ♂+/- | 3 figures ![]() | 8 figures ![]() | |
ndr2m294/m294 (AB) | Homozygous | ♀+/- ♂+/- | 6 figures ![]() | 7 figures ![]() | |
ndr2m294/+ | Heterozygous | ♀+/- ♂+/- | |||
ndr2m294 | Unknown | Unknown | |||
dharmam168/m168; ndr2m294/m294 | Complex | Fig. 6 from Shimizu et al., 2000 | Fig. 7 from Shimizu et al., 2000 | ||
ndr2m294/m294; ndr1cz35/cz35 | Complex | 2 figures from Bennett et al., 2007 | 2 figures from Bennett et al., 2007 | ||
ndr2m294/m294; ndr1cz35/cz35 | Complex | Fig. 1 ![]() | 3 figures ![]() | ||
ndr2m294/m294; ndr1cz35/cz35; c162Tg | Complex | Fig. 1 ![]() | Fig. 1 ![]() | ||
ndr2m294/+; ndr1cz35/cz35 | Complex | ||||
ndr2m294/+; ndr1cz35/+ | Complex | 2 figures from Bennett et al., 2007 | 2 figures from Bennett et al., 2007 |
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Supplemental Information
- Genotyping protocol
- None
- Preiß, H., Kögler, A.C., Mörsdorf, D., Čapek, D., Soh, G.H., Rogers, K.W., Morales-Navarrete, H., Almuedo-Castillo, M., Müller, P. (2022) Regulation of Nodal signaling propagation by receptor interactions and positive feedback. eLIFE. 11:
- Lord, N.D., Carte, A.N., Abitua, P.B., Schier, A.F. (2021) The pattern of Nodal morphogen signaling is shaped by co-receptor expression. eLIFE. 10:
- Soh, G.H., Pomreinke, A.P., Müller, P. (2020) Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism. Cell Reports. 31:107487
- Rogers, K.W., Lord, N.D., Gagnon, J.A., Pauli, A., Zimmerman, S., Aksel, D.C., Reyon, D., Tsai, S.Q., Joung, J.K., Schier, A.F. (2017) Nodal patterning without Lefty inhibitory feedback is functional but fragile. eLIFE. 6
- Gonsar, N., Coughlin, A., Clay-Wright, J.A., Borg, B.R., Kindt, L.M., Liang, J.O. (2016) Temporal and spatial requirements for Nodal-induced anterior mesendoderm and mesoderm in anterior neurulation. Genesis (New York, N.Y. : 2000). 54(1):3-18
- Araya, C., Tawk, M., Girdler, G.C., Costa, M., Carmona-Fontaine, C., and Clarke, J.D. (2014) Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo. Neural Development. 9(1):9
- Lu, P.N., Lund, C., Khuansuwan, S., Schumann, A., Harney-Tolo, M., Gamse, J.T., and Liang, J.O. (2013) Failure in closure of the anterior neural tube causes left isomerization of the zebrafish epithalamus. Developmental Biology. 374(2):333-344
- Lindemann, S., Senkler, J., Auchter, E., and Liang, J.O. (2011) Using zebrafish to learn statistical analysis and mendelian genetics. Zebrafish. 8(2):41-55
- Noche, R.R., Lu, P.N., Goldstein-Kral, L., Glasgow, E., and Liang, J.O. (2011) Circadian rhythms in the pineal organ persist in zebrafish larvae that lack ventral brain. BMC Neuroscience. 12:7
- Pézeron, G., Lambert, G., Dickmeis, T., Strähle, U., Rosa, F.M., and Mourrain, P. (2008) Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. PLoS One. 3(1):e1434
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