Genomic Feature
m145
- ID
- ZDB-ALT-980203-418
- Name
- m145
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 39589568 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Elongated Polypeptide: Stop>Gly (1)
- Flanking Sequence
-
CCCCCCAAACAAACAGTAGTGATTGAAGTGCATCATACCAATGAACTAATTTCAATATAAACTCTAGTTACAATCTTACACATGTACAGATTTACAAACTGGATTGTTAAATCAGAGATAAAAAAACAAACACCTCACTTTAGTGATTATCTGCAAAACTTTGGTTTGTTTCAGAACAAGCTGTTCACTCTAAAGCTGCTGTTGGGTGTTTGTGGAAGTCAGATGATATCAAAGCATACATCTCAAATGCAGCATGTTAGCAGTGTTTATGCAGGCACTGTTAAAACAGAAACAAACTTCCTTTACGGTTTCCAACACAGTGCGACGTGTAAAAACTCTTTCTTTTCTTCCCAGAATGTTGGCTTAAGTTTGACGCTGCATATGTGCACAAGTGTAGAGGAAGACAAAAGCCCATGCTGCTGACCGAAGCAGGCACAATAGCCGCTGCTTTCCTTTATGTACAAAGCATGGAAGACGTCCAACATTTAAATCCAACATTT
A/T AAACGCTCCCACTTCAGTTCCCCACGGTCGGTATGGTTTACTGCTGCTCCCGCTGCTCTGTTGGGATGTGGTGGATGTGGAAACGGAAGAGCTCACGGTGGAAGAAGCCACTGAAGATGCTGTAACGCTGGGGCTGAAGAGTGGGAATCCAGCGGGAAATGATAGAGGGAAGGTTTGAGCTGCAGCTGCAGCAGCTGCTGCGTGAACGGTCGCTGATAACGAAAGCAGAGAAGTGGACAGCGGTGGCACGCAAGGAGCCACACTTCCAGTAGAGGGCGCTCTGAGTGCCGAGTCACTATGGGAGAAAAGGGCTGCACCTCTTTGAGGAGCCTCAGACAGCCTGCCGGAGGAGCTCTCTGAGGAGGGAAGTCCGCTCTGCTGCAGGAACGCAGCAGGAATGGGATGCAAAGCGGCAGCCCAGTGGTGCGGGTGAAGGGCCTGCTGGTGATGGGCTATGGATGTGGTCATGGCGGCTGCTTCCCTCTGCGAGGCACAGCTGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| hey2m145/m145 | Homozygous | Unknown | 3 figures from Jia et al., 2007 | 3 figures from 2 publications | |
| hey2m145/m145 | Homozygous | ♀+/- ♂+/- | Fig. 1 from Becker et al., 2012 | ||
| hey2m145/m145 (AB) | Homozygous | Unknown | 3 figures  from 3 publications | Fig. 8 from Rutenberg et al., 2006 | |
| hey2m145/+ | Heterozygous | Unknown | |||
| hey2m145/m145; f1Tg/+ | Complex | Fig. 2 from Jia et al., 2007 | |||
| hey2m145/m145; sd2Tg; y1Tg | Complex | ||||
| hey2m145/m145; y1Tg | Complex | Fig. 1 from Gray et al., 2007 | |||
| hey2m145/m145 + MO1-gata5 | Complex | Fig. 5 from Jia et al., 2007 | Fig. 5 from Jia et al., 2007 | ||
| hey2m145/m145 + MO1-spi1b | Complex | Fig. 5 from Gray et al., 2007 |
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Supplemental Information
- Genotyping protocol
- None
- Gibb, N., Lazic, S., Yuan, X., Deshwar, A.R., Leslie, M., Wilson, M.D., Scott, I.C. (2018) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development (Cambridge, England). 145(22):
- Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611
- Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., and MacRae, C.A. (2012) In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signaling. Cardiovascular research. 93(3):463-470
- Rowlinson, J.M., and Gering, M. (2010) Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood. 116(12):2046-2056
- Packham, I.M., Gray, C., Heath, P.R., Hellewell, P.G., Ingham, P.W., Crossman, D.C., Milo, M., and Chico, T.J. (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiological Genomics. 38(3):319-327
- Gray, C., Packham, I.M., Wurmser, F., Eastley, N.C., Hellewell, P.G., Ingham, P.W., Crossman, D.C., and Chico, T.J. (2007) Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 27(10):2135-2141
- Jia, H., King, I.N., Chopra, S.S., Wan, H., Ni, T.T., Jiang, C., Guan, X., Wells, S., Srivastava, D., and Zhong, T.P. (2007) Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proceedings of the National Academy of Sciences of the United States of America. 104(35):14008-14013
- Bayliss, P.E., Bellavance, K.L., Whitehead, G.G., Abrams, J.M., Aegerter, S., Robbins, H.S., Cowan, D.B., Keating, M.T., O'reilly, T., Wood, J.M., Roberts, T.M., and Chan, J. (2006) Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2(5):265-273
- Hong, C.C., Peterson, Q.P., Hong, J.Y., and Peterson, R.T. (2006) Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Current biology : CB. 16(13):1366-1372
- Rutenberg, J.B., Fischer, A., Jia, H., Gessler, M., Zhong, T.P., and Mercola, M. (2006) Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (Cambridge, England). 133(21):4381-4390
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