Genomic Feature
ts294e
- ID
- ZDB-ALT-980203-1553
- Name
- ts294e
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 6: 7263580 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 371 (1)
- Flanking Sequence
-
AATTGGTTGAGTTCAGGGAAGGAGGAGGGCAGGTCGGCCGATTGGCCGGTCGCGCAGTCAATCATCCGGTCAGTCTGACATCGGCCTCTGGTGGGTTCACGCGAGAACAGAGCGGGCGCGAACCGCACTTGCGAGAGGCGTCTGAGGTGCGAAAAAGTGCACAACAGCGGCCTCTCACGGATTTGCAAAAACAAAAACTGCAGCCGTACGTACCCACCGGGACGTATTCCGTGTTCTCCAGAAACGTCCGCGGGACTACGTTTCCACAATGAGCCTGGGTTGAACTTTGCTGAATTTAAATTTAACACATACAATATATTTACCAAAATCGTGGATATAATGTGGTTATGCTCTATCCACATAATCACTTTGTACTTCTCTCTTTATAGGAGCTGCTGAAACTGCAGCAGAAAAATATACAGGAAAGCATGCAGTCGGTACAGACACAGCCCAATGCATCAGCCAGCAATGAACACTGGCAGGAAGTCGTTAAACTCCAA
C/T AAAAACTCCACAAACAGGTAAGATATACAACGTTCAGATGAAATGTCTTGACCACTATGCATTTGCTAATATCTGGACTTGAATTTGTTTGTTTTAGAGAGGTCTGAAAATTTGCAGATCTTATACATGTATACCCTTATAGAAATCTATGTATAGTAATCTATGTTTTATCTATAACATGGCCTGTAGGGGTATGAACCTACACTGGTCTCACGGTTCGGTTTGGTTATGATTATCATGTCATCGATTCAGTTCAATTCAATATCTCTGTGCATCAAGGTGCATTGACGATGCTTTTCATCCATAATTATATTTTTTTCTTCACAATACGAAGTGGAGGAAAGTCCCCAGGGTTCAAGTATCTTGGGGTTTTGCTTACGAGTGAGGGAAGGATGGAGTGTGAGATTGACAGGTGGATTGGTGCAACGGCAGCAGTGATGCGGTTGATGTATTGGTCCGTTGTGGTAAAGAAGAAGCTGAGCTGAAAAGCAAAGCTCTTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dzip1ts294e/ts294e | Homozygous | ♀+/- ♂+/- | 22 figures  from 10 publications | 7 figures from 7 publications | |
| dzip1ts294e/ts294e; hsc5Tg | Complex | Fig 1 from Nandamuri et al., 2022 | Fig 1 from Nandamuri et al., 2022 | ||
| dzip1ts294e/ts294e; rw0Tg | Complex | Fig. 7 from Sittaramane et al., 2013 | Fig. 7 from Sittaramane et al., 2013 | ||
| dzip1ts294e/ts294e; s896Tg; z200Tg | Complex | Fig 7 from Nandamuri et al., 2022 | Fig 7 from Nandamuri et al., 2022 | ||
| dzip1ts294e/ts294e; vu234Tg; z200Tg | Complex | Fig 6 from Nandamuri et al., 2022 | Fig 6 from Nandamuri et al., 2022 | ||
| dzip1ts294e/ts294e; z200Tg | Complex | Fig 2 from Nandamuri et al., 2022 | 2 figures from Nandamuri et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Nandamuri, S.P., Lusk, S., Kwan, K.M. (2022) Loss of zebrafish dzip1 results in inappropriate recruitment of periocular mesenchyme to the optic fissure and ocular coloboma. PLoS One. 17:e0265327
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Campinho, P., Lamperti, P., Boselli, F., Vilfan, A., Vermot, J. (2020) Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta. Cell Reports. 31:107505
- Peralta, M., Ortiz Lopez, L., Jerabkova, K., Lucchesi, T., Vitre, B., Han, D., Guillemot, L., Dingare, C., Sumara, I., Mercader, N., Lecaudey, V., Delaval, B., Meilhac, S.M., Vermot, J. (2020) Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis. Cell Reports. 32:107932
- Jacobs, C.T., Huang, P. (2019) Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish. eLIFE. 8:
- Cantaut-Belarif, Y., Sternberg, J.R., Thouvenin, O., Wyart, C., Bardet, P.L. (2018) The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis. Current biology : CB. 28(15):2479-2486.e4
- Ma, R.C., Jacobs, C.T., Sharma, P., Kocha, K.M., Huang, P. (2018) Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish. PLoS Genetics. 14:e1007775
- Hudish, L.I., Galati, D.F., Ravanelli, A.M., Pearson, C.G., Huang, P., Appel, B. (2016) miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development (Cambridge, England). 143(13):2292-304
- Boyd, P.J., Cunliffe, V.T., Roy, S., Wood, J.D. (2015) Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open. 4(10):1336-43
- Maurya, A.K., Ben, J., Zhao, Z., Lee, R.T., Niah, W., Ng, A.S., Iyu, A., Yu, W., Elworthy, S., van Eeden, F.J., and Ingham, P.W. (2013) Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genetics. 9(12):e1003955
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