Genomic Feature
tt221
- ID
- ZDB-ALT-980203-1533
- Name
- tt221
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 21: 22474609 (GRCz11) (1) Details
- Nucleotide change
- A/C
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>Stop at position 1111 (1)
- Flanking Sequence
-
TATCATGACACAGATGAAATAAATAAGGTATTAGAGATGAGTTATTAAAACTATTACGTTTAGAAATGTGTTGAAAGATTTTCTCTCCGTTAAACAGAAATTGGGAGAAAAAAAATAAACAGGGGGCGAATAATTCAGACTTCAATGTTTTGTTTTAAGCTTTGTCCCAACTGTGAAATGACTATAAAAGCAAACAGAATGTGACAAATAAACATGCCTTGCGTTTGCTCAGTTCCTCTACTTTATCTAGATTGGTCTGCAGCCGCTTCCTCTCCTGCTCCAGCTCTCGTACACGTTTCTGTAACTTCATGAAAACGCTGAGGTCCATGGCAGCCTTCTCTATGCCCATCTCCTGCAGCAAAACAAATCCCATTAATGCTCATCATGAGCTGCCTTTGTTTCCCTTTCAAAAGCCTATTTTATAAGTTGTCACACATCTTTACCTCCACCTGCTGGATGGTGTCATCAGTGTCCCCCACCTCTGACAAGCTAATTGAGGG
A/C TAGTTGGAGTCTGAACCCAAGCTGCTCTGGTTAGATGGGTTTCTCCGATGCCCAGGATGAAACTAGAGTGTGGAAAAAAATAAAAGTTTAAAAACAACAACAACAACAACAACAACAACAACAACAACAACAACAACGAAAAGAAAACCCAAGAGGCCTATTGCACAAATCCAAGTGAACAAACTCAGGTTTCAGACTAAGTTTTAAGTTGACAAAACCAAACAAATTCAACTTAGTTAGCATCCGGATAGGGGCTGTCACAGTATTGGTGCTTTAACATAGAGTTTGTGTTTAACTCTGGACCACTGCTGAAGAAGTATAATTTAAAAAGGCAATTAAAGAAAATATTATATCAGTGCAAATTAGGTCGACTGATTTTAATAATGTAGGTTCACAAATAGATCACTTCATCTCTTGAAGTCTTAATTAAAACATATTTATGTAAATATTAAAATGTAAATTTGAACTTAAAGCTATTACTGATATTAATTGACAATTCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| myo5btt221/tt221 | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | Fig. 1 from Sonal et al., 2014 | |
| myo5btt221/tt221 | Homozygous | Unknown | 2 figures from Phatak et al., 2021 | Fig 2 from Phatak et al., 2021 | |
| myo5btt221 | Unknown | Unknown | Fig. for (tt221) from Phenotype Annotation (1994-2006) | ||
| myo5btt221/tt221; zf106Tg | Complex | Fig. 3 from Sidhaye et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Phatak, M., Kulkarni, S., Miles, L.B., Anjum, N., Dworkin, S., Sonawane, M. (2021) Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish. PLoS Genetics. 17:e1009823
- Sidhaye, J., Pinto, C.S., Dharap, S., Jacob, T., Bhargava, S., Sonawane, M. (2016) The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease. Mechanisms of Development. 142:62-74
- Sonal, ., Sidhaye, J., Phatak, M., Banerjee, S., Mulay, A., Deshpande, O., Bhide, S., Jacob, T., Gehring, I., Nuesslein-Volhard, C., Sonawane, M. (2014) Myosin Vb Mediated Plasma Membrane Homeostasis Regulates Peridermal Cell Size and Maintains Tissue Homeostasis in the Zebrafish Epidermis. PLoS Genetics. 10:e1004614
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:255-262
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