Gene
myo5b
- ID
- ZDB-GENE-031219-7
- Name
- myosin VB
- Symbol
- myo5b Nomenclature History
- Previous Names
-
- cb1077 (1)
- gsp
- si:ch73-112l6.5
- unm t30834
- unm t30835
- unm_t30834
- unm_t30835
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including endocytic recycling; growth involved in heart morphogenesis; and intestinal lipid absorption. Predicted to localize to myosin complex. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Is expressed in several structures, including EVL; gut; periderm; pronephric duct; and sensory system. Orthologous to human MYO5B (myosin VB).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1077 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| microvillus inclusion disease | Alliance | Diarrhea 2, with microvillus atrophy, with or without cholestasis | 251850 |
| Cholestasis, progressive familial intrahepatic, 10 | 619868 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| microvillus inclusion disease | myo5bt30834/t30834 | standard conditions | Sidhaye et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR002710 | Dilute domain |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Domain | IPR036103 | Class V myosin, motor domain |
| Domain | IPR037990 | Myosin 5b, cargo-binding domain |
| Family | IPR052072 | Vascular development regulator domain-containing protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class V myosin, motor domain | Dilute domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin 5b, cargo-binding domain | Myosin, N-terminal, SH3-like | P-loop containing nucleoside triphosphate hydrolase | Vascular development regulator domain-containing protein |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PIE0
|
1191 | ||||||||
|
UniProtKB:A0A8M3ALG0
|
1838 | ||||||||
|
UniProtKB:A0A8M9PCR9
|
1814 | ||||||||
|
UniProtKB:A0A8M9P3E4
|
1840 | ||||||||
|
UniProtKB:A0A8M9PQJ8
|
1840 | ||||||||
|
UniProtKB:F1QKS0
|
1838 |
Interactions and Pathways
No data available
Plasmids
No data available