Gene

myo5b

ID
ZDB-GENE-031219-7
Name
myosin VB
Symbol
myo5b Nomenclature History
Previous Names
  • cb1077 (1)
  • gsp
  • si:ch73-112l6.5
  • unm t30834
  • unm t30835
  • unm_t30834
  • unm_t30835
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including endocytic recycling; growth involved in heart morphogenesis; and intestinal lipid absorption. Predicted to localize to myosin complex. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Is expressed in several structures, including EVL; gut; periderm; pronephric duct; and sensory system. Orthologous to human MYO5B (myosin VB).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myo5b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
microvillus inclusion disease Alliance Diarrhea 2, with microvillus atrophy, with or without cholestasis 251850
Cholestasis, progressive familial intrahepatic, 10 619868
Associated With myo5b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR002710 Dilute domain
Domain IPR004009 Myosin, N-terminal, SH3-like
Domain IPR036103 Class V myosin, motor domain
Domain IPR037990 Myosin 5b, cargo-binding domain
Family IPR052072 Vascular development regulator domain-containing protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Class V myosin, motor domain Dilute domain IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin 5b, cargo-binding domain Myosin, N-terminal, SH3-like P-loop containing nucleoside triphosphate hydrolase Vascular development regulator domain-containing protein
UniProtKB:A0A8M9PIE0 1191
UniProtKB:A0A8M3ALG0 1838
UniProtKB:A0A8M9PCR9 1814
UniProtKB:A0A8M9P3E4 1840
UniProtKB:A0A8M9PQJ8 1840
UniProtKB:F1QKS0 1838
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA myo5b-201 (1) Ensembl 5,661 nt
mRNA myo5b-202 (1) Ensembl 828 nt
mRNA myo5b-203 (1) Ensembl 7,698 nt
mRNA myo5b-204 (1) Ensembl 854 nt
mRNA myo5b-205 (1) Ensembl 8,194 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations