Gene

myo5b

ID

ZDB-GENE-031219-7

Name

myosin VB

Symbol

myo5b Nomenclature History

Previous Names

cb1077 (1)
gsp
si:ch73-112l6.5
unm t30834
unm t30835
unm_t30834
unm_t30835

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including endocytic recycling; growth involved in heart morphogenesis; and intestinal lipid absorption. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and vesicle. Is expressed in several structures, including EVL; gut; periderm; pronephric duct; and sensory system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease and progressive familial intrahepatic cholestasis. Orthologous to human MYO5B (myosin VB).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb1077 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 30 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
microvillus inclusion disease	Alliance	Diarrhea 2, with microvillus atrophy, with or without cholestasis	251850
		Cholestasis, progressive familial intrahepatic, 10	619868

Associated With myo5b Via Experimental Models

Human Disease	Fish	Conditions	Citations
microvillus inclusion disease	myo5b^{t30834/t30834}	standard conditions	Sidhaye et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR002710	Dilute domain
Domain	IPR004009	Myosin, N-terminal, SH3-like
Domain	IPR036103	Class V myosin, motor domain
Domain	IPR037990	Myosin 5b, cargo-binding domain
Family	IPR052072	Vascular development regulator domain-containing protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class V myosin, motor domain	Dilute domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin 5b, cargo-binding domain	Myosin, N-terminal, SH3-like	P-loop containing nucleoside triphosphate hydrolase	Vascular development regulator domain-containing protein
UniProtKB:A0A8M9PIE0 InterPro	1191
UniProtKB:A0A8M3ALG0 InterPro	1838
UniProtKB:A0A8M9PCR9 InterPro	1814
UniProtKB:A0A8M9P3E4 InterPro	1840
UniProtKB:A0A8M9PQJ8 InterPro	1840
UniProtKB:F1QKS0 InterPro	1838

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myo5b-201 (1) Ensembl	Ensembl	5,661 nt	Select Tool ZFIN BLAST
mRNA	myo5b-202 (1) Ensembl	Ensembl	828 nt	Select Tool ZFIN BLAST
mRNA	myo5b-203 (1) Ensembl	Ensembl	7,698 nt	Select Tool ZFIN BLAST
mRNA	myo5b-204 (1) Ensembl	Ensembl	854 nt	Select Tool ZFIN BLAST
mRNA	myo5b-205 (1) Ensembl	Ensembl	8,194 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations