Gene

myo5b

ID
ZDB-GENE-031219-7
Name
myosin VB
Symbol
myo5b Nomenclature History
Previous Names
  • cb1077 (1)
  • gsp
  • si:ch73-112l6.5
  • unm t30834
  • unm t30835
  • unm_t30834
  • unm_t30835
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in several processes, including endocytic recycling; growth involved in heart morphogenesis; and intestinal lipid absorption. Predicted to localize to actin cytoskeleton; cytoplasm; and vesicle. Is expressed in several structures, including EVL; gut; periderm; pronephric duct; and sensory system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Orthologous to human MYO5B (myosin VB).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myo5b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
microvillus inclusion disease Alliance Microvillus inclusion disease 251850
Associated With myo5b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002710 Dilute domain
Domain IPR004009 Myosin, N-terminal, SH3-like
Domain IPR036103 Class V myosin, motor domain
Domain IPR037990 Myosin 5b, cargo-binding domain
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Class V myosin, motor domain Dilute domain IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin 5b, cargo-binding domain Myosin head, motor domain Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A0R4IB90 285
UniProtKB:A0A286YAD0 1812
UniProtKB:A0A0R4IJN0 263
UniProtKB:A0A0R4IPW9 1839
UniProtKB:F1QKS0 1838
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations