Genomic Feature
tn207b
- ID
- ZDB-ALT-980203-1509
- Name
- tn207b
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 17081016 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GGATATCATGGAGGGAGGTGGTTTGCGTAACGTTACACAGCAGCCAATTAAACGCCTGAGAAGGAAATGCAGAACAAAAGGTTACTAAAATGTTTCATCGATATTGACCAATGCATTTCTATTCCTTTTCTAGCTGTTTATTTAGAGGTTTCTAAATCTTTCATCAGTGACCTAATATATAAAGGTATTACAAGGAATTATTTAACTGAAGGCAGATATTCAATAATAATCTATGTTTGCAAAATTTGGAACAAAAAAAACAGTGATGACATTAATCAAAATGTCAGAGTGATTATCAGAGGAAAATATTGCTGACCTCCATGGCGAACACCCTGCAGGCTGATTTGCGGAGTGCATGCTTCATAGCCACCTCCAGGCCCTCTAGGTCATGATGCTGGATGACAAATGCCAACACAGGCCACTGAAAGTTCCGTTCACCCTTGCTGAGAGAGCCATGGGCTGAGATCAGTCGAGACAACTCAGGAGAAGGATGACGAAGC
A/T ACGATGACCCAACTTCTGTAGAAAAAGGCAATCTCTTAAATGCAAAACATTTAAACCTAACTTGCCATACTGCATTTTAACAAAATACCAACATTTTAGTGGTAAACACAAAACAAACAAAAGTATTGAAAAATCTGCGCTAATATTGCTATGATGATTCATTTGAGTGCATAAATATGGCAGTTTATTGCTATGCATCAGTTTATTAGTGCATTTTAGACAACAACAAACAAATTGGTTCGATTCCCAGGTGCACTAACCAACGAAATGTATACCATTAATGCAATTTGCTTCGAATAAAAGCCTATAACAAATGGAAAATATACAGAGTAACATACCCAACTAATTTATACTAAACAAACTTTGCCTGTAAAACCCAGTCCTATAATAGCAGGCAAAAACCTGACAACATGTAAACAGTTTGTCATGCTGTCTTCACACAATGAGCAAATAAAACGCGCTACATTTTGAGTTTACTCGCTTCATTTGCGGGTCAAATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mycbp2tn207b/tn207b | Homozygous | ♀+/- ♂+/- | 6 figures from 6 publications | ||
| mycbp2tn207b/+; mycbp2tp203/+; nkhspGFF62ATg; p201Tg | Complex | Fig. 4  from Bremer et al., 2019 | |||
| mycbp2tn207b/tn207b; nkhspGFF62ATg; p201Tg | Complex | 4 figures from Bremer et al., 2019 | |||
| mycbp2tn207b/tn207b; nkhspGFF62ATg; p411Tg; ue2Tg | Complex | Fig. 6 from Bremer et al., 2019 | |||
| mycbp2tn207b/tn207b; nkhspGFF62ATg; p411Tg; zf167Tg | Complex | Fig. 6 from Bremer et al., 2019 | |||
| mycbp2tn207b/tn207b; nkhspGFF62ATg; p412Tg | Complex | Fig. 7 from Bremer et al., 2019 | |||
| cyfip2p400/p400; mycbp2tn207b/tn207b; nkhspGFF62ATg; p201Tg | Complex | Fig. 8 from Bremer et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Bremer, J., Marsden, K.C., Miller, A., Granato, M. (2019) The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology. 2:195
- Hendricks, M., Mathuru, A.S., Wang, H., Silander, O., Kee, M.Z., and Jesuthasan, S. (2008) Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for commissure formation. Molecular and cellular neurosciences. 37(2):271-283
- D'Souza, J., Hendricks, M., Le Guyader, S., Subburaju, S., Grunewald, B., Scholich, K., and Jesuthasan, S. (2005) Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc). Development (Cambridge, England). 132(2):247-256
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438
- Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389
- Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R.N., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:391-398
- Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England). 123:439-450
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