Genomic Feature
tm272a
- ID
- ZDB-ALT-980203-1438
- Name
- tm272a
- Synonyms
-
- AM072A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 20232182 (GRCz11) (1) Details
- Nucleotide change
- A/G
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C in Exon 3 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Leu>Pro at position 38 (1)
- Flanking Sequence
-
TGGAGCCACAAAGCAGCGTAAACAGGCCAAATAAAGGAAGATGAACGTTTGACCAAATGTCTGCTTTTCTCACCGTTTTCCGACTGCCACCAGGACTTCTTGCGATGTGGTTTGAAGGTGGTGATGACGTTCTCGATGCGGTGGCTTACGGGGTTGGACTGAGGATCATAAGGCCGCCGTGAATCACACTGGAAACACTTCTTCTCCTCCTATGTAAAGTCAAGGGTCGAAATCAGAAAGTATCAGTTCTGCAGCATCATCATCTTCACAAAGAAATAAGCATGTTTATATGCACGCCAGTATGCTGAGAAATCACAAAATCCAGCTTACTAAAATTACCTGTTGTATTAATTACATGAAAGCAAACCGAATTTACAAGTACACTAACTGCGAGAACAGATGAGGACCTTACCTGCAGATGGCTGACAATGCAGTAGGGTTCTCTCCTCCGCAGGCCACAGGTGGATGATGCTTTCAGGTTGGCTTCTCGACCCACCAAG
A/G GGTCACCGGTTGCAGGATAGCAGCTTCCATGAGTGCAGCCGTGAGCAGCATCAGGCTCCTGTGCACTGACCGCTGACAGGACTTTTAAGTAGACAAAGAGAATCAGAACAGAACATGGTTGTTTTTATAATGTAGCTCAAATTGACTGTTGAGTCTTTAGTTCACATGATTTTTTTTTTTTTTTTTTGTTCATTTGGCAGTTTGGCAAACCAGAGCTCAAGCAATTTTCCATTAATGCTTAGCAAAGGCCAAGTTTCCACTAAACATCCCTTTAGGCTGTAAGAATGAGGAGCAACGAAATGAGGGGAAATTATTTGGCAATATCAAATGATGCAAAAATCAGGAATATTGTGGTTTCTGTGTGATCAGACATGTTTTCTCAAGTATTCCTTGTCTCACTATAGACAGTAGTTTGCTTAAAACTACGGAATGTTTCTTTTCTCTATGAAATTGTTCAAAAATGTAAAATGGAACTAAATATTATTACAGATTGTTTTTCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lamb2tm272a/tm272a | Homozygous | ♀+/- ♂+/- | 9 figures  from 3 publications | 2 figures from Jacoby et al., 2009 | |
| lamb2tm272a/tm272a (TU) | Homozygous | ♀+/- ♂+/- | Fig. 2 from Berger et al., 2012 | ||
| lamb2tm272a/tm272a; i104Tg | Complex | Fig. 7 from Jacoby et al., 2009 | |||
| lama2teg15a/teg15a; lamb2tm272a/tm272a | Complex | text only from Jacoby et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Berger, J., Sztal, T., and Currie, P.D. (2012) Quantification of birefringence readily measures the level of muscle damage in zebrafish. Biochemical and Biophysical Research Communications. 423(4):785-788
- Jacoby, A.S., Busch-Nentwich, E., Bryson-Richardson, R.J., Hall, T.E., Berger, J., Berger, S., Sonntag, C., Sachs, C., Geisler, R., Stemple, D.L., and Currie, P.D. (2009) The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment. Development (Cambridge, England). 136(19):3367-3376
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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