Gene
lamb2
- ID
- ZDB-GENE-081030-4
- Name
- laminin, beta 2 (laminin S)
- Symbol
- lamb2 Nomenclature History
- Previous Names
-
- si:dkey-32e6.2
- sof
- softy (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in several processes, including basement membrane assembly; glial cell development; and muscle attachment. Predicted to localize to laminin complex. Is expressed in several structures, including adaxial cell; head; musculature system; nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 5 | Alliance | Nephrotic syndrome, type 5, with or without ocular abnormalities | 614199 |
| Pierson syndrome | Alliance | Pierson syndrome | 609049 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EGF-like domain | Laminin IV type B | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B8V2
|
1794 | |||||
|
UniProtKB:B7ZDA6
|
1782 |
Interactions and Pathways
No data available
Plasmids
No data available