Gene

lamb2

ID

ZDB-GENE-081030-4

Name

laminin, beta 2 (laminin S)

Symbol

lamb2 Nomenclature History

Previous Names

si:dkey-32e6.2
sof
softy (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in basement membrane assembly; muscle attachment; and somite development. Predicted to localize to laminin complex. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Is expressed in several structures, including adaxial cell; head; musculature system; nervous system; and solid lens vesicle. Orthologous to human LAMB2 (laminin subunit beta 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lamb2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 5	Alliance	Nephrotic syndrome, type 5, with or without ocular abnormalities	614199
Pierson syndrome	Alliance	Pierson syndrome	609049

Associated With lamb2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR013015	Laminin IV type B
Family	IPR050440	Laminin/Netrin Extracellular Matrix