Genomic Feature
tr241
- ID
- ZDB-ALT-980203-1373
- Name
- tr241
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 19: 40026717 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 491 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- at position 167 (1)
- Flanking Sequence
-
GAATGGGGATGCGCGGTGGCATGGGCATGGGGATGGGTATGGGCATGGGAATGGGAATGGGGATGGGGATGGGAATGGGAAACCCGAACTTTCGAAATCAAAACCAGCACCATTTTCAAAACCGAGGCCCACAAATGGGTGGTGGATTTAGGCAGAATCAGGGAAATCAAGGCAACCAGGTATCTACACAACAGAAGCCGCAGGAACCCGCACAGAACAAGCCCGTCGTGCAGACTCCTCCTGCGCAAGGCCCCGGTCAGGCCCAGCAGGCCGCCAACAAAGGCCCGACGCCCCAGCAGACTCCCACCGTCGCTCCGCCGAAAATCCAGTCTGCTCCACCGAAGATCCAGTCTCCTCCGCCGAAGATTCAGTCTCCTCCGCCAGCACAGAATAACGCGAAGACGCCAGAAATAGCTTCCCCTCAAAACCAGCAAAGGAAGAACCTACCCAAACCCGCGATGGGGAATGGCCAGAAGCCGCCTGCTCCCTTGAAGCAAGAG
C/T AGACGCCAGCACCAACACCCCCACCAGCACAACAACAGCAGCAACAGCAACAACAACAAAAACAGACTCCCGCAAACGAGCAGAGCTCTCAGCCCCAGGTAAATATATGAACGTTTTAAGTCTAATAAAGTCGTTTAGTGAGAAATATTACCATTTGCAATAGTTAGAGGCGCAAATGTGTCGTCTTGAAACATGTGTCGGTTACTAAAGGGCTAGGATGTAGCCGAGGCAGATCCGCCATTTTATAGAGCCTTTAACAAAGGCTGAACGCCGCACCGGTTCCTCGTCGCCCATTTCAGTATAAAAATGCATTTTAACTGCTTGGTTGAGATTATAAGTTAAAGTAATTATTTCCAAGAGTATATTTTGACACCTTTTTGGAACATTTCTTCAAATGTTAAATGTTTTATTACACAACGTTTAGCAACTGCTTTAACGTTACTAAAATTCTTGAGCTATGGTTAGTGTAAGTTGGTGAAATCAAGGTTTAATTTCGTAGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sfpqtr241/tr241 | Homozygous | ♀+/- ♂+/- | 9 figures  from 5 publications | Fig. 6 from Lowery et al., 2007 | |
| sfpqtr241/+ (AB) | Heterozygous | Unknown | |||
| sfpqtr241/+ (AB/TL) | Heterozygous | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Lowery, L.A., De Rienzo, G., Gutzman, J.H., and Sive, H. (2009) Characterization and Classification of Zebrafish Brain Morphology Mutants. The Anatomical record. 292(1):94-106
- Lowery, L.A., Rubin, J., and Sive, H. (2007) whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1347-1357
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Jiang, Y.J., Brand, M., Heisenberg, C.P., Beuchle, D., Furutani-Seiki, M., Kelsh, R.N., Warga, R.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development (Cambridge, England). 123:205-216
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