Genomic Feature
tr265
- ID
- ZDB-ALT-980203-1344
- Name
- tr265
- Synonyms
-
- AR65A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 20075003 (GRCz11) (1) Details
- Nucleotide change
- T/C
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>G at position 1476 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Glu>Gly at position 456 (1)
- Flanking Sequence
-
GAAGAGTGACGTTGATAACTTTTTTGATTGGATGGAATGGGTCATCCAAGGAATCATTTAAGTGTTCGTAGTTCAAGATCAAAGGATGAGCTTTGAAAATCTGAGAAGTACAAAAACAAACAAAAACTAAATATGTGAGAACGAAAAAATAATGTGTGTTAATCTAACGAAGTATGTGTGTATCAGGATTCCTGCAAATACCTTGATAAGCTTGGAAAAGGTCTCGTAGATGAAAATGAGAGAGATCAAAATGGAGAAGATCTCCTGGGTGAAGCGCGAGATGAAACGGACCAGGAAGCTTCCCTCCACTGCCATAATGATCACCACAATGACGATCAGCCACATACCCACCCAAACACGGCCAACGATGTACTCAAAGCCATACCCCTTGCAGAACTGAATGGAAGATGATGCAAGTGTTTTGATTGATGAGCAAAGTAAAACGCATTGTTAAAATCTCAATTCTCAATGATAAAGGCCTCACCTGAAAGAACGCCTCC
T/C CAAACACCATTAATGGTCCAGTAAACCCTATGACGAGAACTGGTTGAGCCGCAAAGAGACAAAAGATGACACCCTGCACGCAGGTGGAGACCATCATCTCAGAGACCCCCATCATGTGCTCCGTCTTATCCGCTAAAACACAGGAATGGATTGAATGTTAAAGATATAGAAGTTTTATAAAACAATGAGAATTTACTCAATGTAATATATCCTCCTGAGACCCCGCCCTTTGACTTGTGTCCTCTGTACATTGCATTTTCATGAAATTTCTTTTAATTTTTTAAGCTCTCTGCCAAGTCCTGTTGTACTGTTCAGAGGACATCCTGGGCTTTCTAGTGAGATGTCATTTGATTGGCTGGCATGCTAAGAACCACTTCTTGCACTGCATCCAATATGGCCGACTTACAAAAAAGCACATTTTATGAGAAAGAGAGAGGCATAAAGTTTAGGTTTTTAAATGTTTTTTTTTTAATTATTATTATTAAATATATATTTGTTTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| slc4a1atr265/tr265 | Homozygous | Unknown | 2 figures from 2 publications | text only from Bennett et al., 2001 | |
| slc4a1atr265/tr265 | Homozygous | ♀+/- ♂+/- | 8 figures  from 3 publications | ||
| slc4a1atr265/+ (AB) | Heterozygous | Unknown | |||
| slc4a1atr265/tr265; f2Tg | Complex | 3 figures from Sun et al., 2009 | 2 figures from Sun et al., 2009 | ||
| slc4a1atr265/tr265; w26Tg | Complex | ||||
| slc4a1atr265/tr265; xu072Tg | Complex | Fig. S5 from Ding et al., 2016 | |||
| slc4a1atr265/tr265; xu073Tg | Complex | Fig. S5 from Ding et al., 2016 | |||
| slc4a1atr265/tr265; dnajb6bxu0411Gt/+ | Complex | Fig. S5 from Ding et al., 2016 | |||
| slc4a1atr265/tr265; mtorxu015Gt/+ | Complex | 2 figures from Ding et al., 2011 |
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Supplemental Information
- Genotyping protocol
- tr265.pdf
- Ding, Y., Long, P.A., Bos, J.M., Shih, Y.H., Ma, X., Sundsbak, R.S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M.J., Lin, X., Ekker, S.C., Redfield, M.M., Olson, T.M., Xu, X. (2016) A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.. JCI insight. 1(14)
- Ding, Y., Sun, X., Huang, W., Hoage, T., Redfield, M., Kushwaha, S., Sivasubbu, S., Lin, X., Ekker, S., and Xu, X. (2011) Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish. Circulation research. 109(6):658-69
- Hoage, T., Sun, X., and Xu, X. (2011) Functions of the Wnt/β-catenin pathway in an anemia-induced zebrafish model of cardiomyopathy are location dependent. Biochemical and Biophysical Research Communications. 415(3):490-6
- Sun, X., Hoage, T., Bai, P., Ding, Y., Chen, Z., Zhang, R., Huang, W., Jahangir, A., Paw, B., Li, Y.G., and Xu, X. (2009) Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One. 4(8):e6596
- Paw, B.H., Davidson, A.J., Zhou, Y., Li, R., Pratt, S.J., Lee, C., Trede, N.S., Brownlie, A., Donovan, A., Liao, E.C., Ziai, J.M., Drejer, A.H., Guo, W., Kim, C.H., Gwynn, B., Peters, L.L., Chernova, M.N., Alper, S.L., Zapata, A., Wickramasinghe, S.N., Lee, M.J., Lux, S.E., Fritz, A., Postlethwait, J.H., and Zon, L.I. (2003) Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nature Genetics. 34(1):59-64
- Bennett, C.M., Kanki, J.P., Rhodes, J., Liu, T.X., Paw, B.H., Kieran, M.W., Langenau, D.M., Delahaye-Brown, A., Zon, L.I., Fleming, M.D., and Look, A.T. (2001) Myelopoiesis in the zebrafish, Danio rerio. Blood. 98(3):643-651
- Paw, B.H. (2001) Cloning of the zebrafish retsina blood mutation: a genetic model for dyserythropoiesis and erythroid cytokinesis. Blood cells, molecules & diseases. 27(1):62-64
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319
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