PUBLICATION

Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency

Authors
Paw, B.H., Davidson, A.J., Zhou, Y., Li, R., Pratt, S.J., Lee, C., Trede, N.S., Brownlie, A., Donovan, A., Liao, E.C., Ziai, J.M., Drejer, A.H., Guo, W., Kim, C.H., Gwynn, B., Peters, L.L., Chernova, M.N., Alper, S.L., Zapata, A., Wickramasinghe, S.N., Lee, M.J., Lux, S.E., Fritz, A., Postlethwait, J.H., and Zon, L.I.
ID
ZDB-PUB-030408-10
Date
2003
Source
Nature Genetics   34(1): 59-64 (Journal)
Registered Authors
Brownlie, Alison J., Davidson, Alan, Donovan, Adriana, Fritz, Andreas, Guo, Wen, Lee, Charles, Liao, Eric, Paw, Barry, Postlethwait, John H., Pratt, Stephen J., Trede, Nick, Zhou, Yi, Ziai, James, Zon, Leonard I.
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Anemia, Dyserythropoietic, Congenital/genetics
  • Animals
  • Animals, Genetically Modified
  • Anion Exchange Protein 1, Erythrocyte/deficiency*
  • Anion Exchange Protein 1, Erythrocyte/genetics*
  • Erythropoiesis/genetics*
  • Gene Expression Regulation, Developmental
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mitosis/genetics*
  • Molecular Sequence Data
  • Mutation*
  • Phenotype
  • Zebrafish/blood
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed
12669066 Full text @ Nat. Genet.
Abstract
Most eukaryotic cell types use a common program to regulate the process of cell division. During mitosis, successful partitioning of the genetic material depends on spatially coordinated chromosome movement and cell cleavage. Here we characterize a zebrafish mutant, retsina (ret), that exhibits an erythroid-specific defect in cell division with marked dyserythropoiesis similar to human congenital dyserythropoietic anemia. Erythroblasts from ret fish show binuclearity and undergo apoptosis due to a failure in the completion of chromosome segregation and cytokinesis. Through positional cloning, we show that the ret mutation is in a gene (slc4a1) encoding the anion exchanger 1 (also called band 3 and AE1), an erythroid-specific cytoskeletal protein. We further show an association between deficiency in Slc4a1 and mitotic defects in the mouse. Rescue experiments in ret zebrafish embryos expressing transgenic slc4a1 with a variety of mutations show that the requirement for band 3 in normal erythroid mitosis is mediated through its protein 4.1R-binding domains. Our report establishes an evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping