Genomic Feature
tc244b
- ID
- ZDB-ALT-980203-1317
- Name
- tc244b
- Synonyms
-
- AC044B (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 25: 18126890 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Leu>Stop (1)
- Flanking Sequence
-
CTCAGACCATTCAAGATGTACGTGACTTTTCTCCTTTGGTGGAACATTAAAGGCCTTTTCTTTGGGCCTCTGTGGTCCCTGGTGATAAAATGCAAGTCATCAGATAAGAGGACTTCATAACTATATATTGAGGTCTTATGGAAAGAAAAATGTGAAAAGTAATAATGTTGTAAACAAGTTGCCAGGTTATTTTTTGACTCTCAAATTGCCTTTAACAACCATTTTATGATATTACCAAGAACCACGGTTTCAGCAAAACATTTTCTTTAATGATAATCTTTTTTTAAAAACGACACATCTTCGATGGCCAGAGGGTGAGTAAACGAACAGCTAATGTATATTTTTGTGTAAACTAAGACTCACCATTTGTACTATGTTGCGCTGATGTTGTCGACGCTGTTGTAGTTGTTGTTATTGTTGTTTTTGTGGATGTGGGACATGGCGGTGGCTCGCAGTCCTCAGCATCTCTTGATGAATTGGCAGTGTTGAAAAAATCCTCC
A/T AAAATTCAAAATACTTCGCCGTAAGCCACATCTCCTCTACATAGTGACACTCAAAGTCAAGCATTGAATCCTCCTGAAGGTACAGAAAAAAAGATGATTTACAAGCAGTTCATTTGTTGCAATGTTGTCAAGATACTAGTTTATTTATTTGACATAGATCTTCCATTTAAATAATAAACAAATAACTGTAAAACTATAATAAATCATATTGAATAATGCTCTCTAAAATCAATACAAAATAGATGTTTATTGTTATCTTAACTGTCAAACCTTTGACTAATTTTGCTAATTTTATTTTACTTTAATATAACACCAGAAACAAATATTGATATATGAAATATGTTAATAAAAAGTTTAATAAAAAATAGTTATTTTACAGAAATTATTTTAGACTAAGACAGAAAACAATTGTACAAATACCGTTGACTGTTTTACCTCACATTAATAACTAAAAGCAATGTGATTACCCTTAAGAAAACAAAGATTTTGTTTTTTAGTAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kitlgatc244b/tc244b | Homozygous | ♀+/- ♂+/- | 3 figures  from 3 publications | ||
| kitlgatc244b | Unknown | Unknown | Fig. for (tc244b) from Phenotype Annotation (1994-2006) | ||
| kitlgatc244b/tc244b; w47Tg | Complex | Fig. 9 from Dooley et al., 2013 | |||
| kitlgatc244b/tc244b; w47Tg; zf148Tg | Complex | Fig. 9 from Dooley et al., 2013 | Fig. 9 from Dooley et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Frantz, W.T., Iyengar, S., Neiswender, J., Cousineau, A., Maehr, R., Ceol, C.J. (2023) Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. eLIFE. 12:
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Tryon, R.C., Johnson, S.L. (2014) Clonal Analysis of kit ligand a Functional Expression Reveals Lineage-Specific Competence to Promote Melanocyte Rescue in the Mutant Regenerating Caudal Fin. PLoS One. 9:e102317
- Dooley, C.M., Mongera, A., Walderich, B., and Nüsslein-Volhard, C. (2013) On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development (Cambridge, England). 140(5):1003-1013
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389
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