Gene
kitlga
- ID
- ZDB-GENE-070424-1
- Name
- kit ligand a
- Symbol
- kitlga Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within melanocyte differentiation. Predicted to be located in several cellular components, including extracellular region; filopodium; and lamellipodium. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; endocrine system; muscle; neural crest cell; and segmental plate. Human ortholog(s) of this gene implicated in Waardenburg syndrome; autosomal dominant nonsyndromic deafness 69; familial progressive hyperpigmentation with or without hypopigmentation; and pigmentation disease. Orthologous to human KITLG (KIT ligand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 69 | Alliance | Deafness, autosomal dominant 69, unilateral or asymmetric | 616697 |
| familial progressive hyperpigmentation with or without hypopigmentation | Alliance | Hyperpigmentation with or without hypopigmentation | 145250 |
| Waardenburg syndrome, type 2F | 619947 | ||
| [Skin/hair/eye pigmentation 7, blond/brown hair] | 611664 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Stem cell factor |
|---|---|---|---|---|
| UniProtKB:Q56JH6 | InterPro | 272 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kitlga-201
(1)
|
Ensembl | 1,613 nt | ||
| mRNA |
kitlga-202
(1)
|
Ensembl | 801 nt | ||
| mRNA |
kitlga-203
(1)
|
Ensembl | 819 nt |
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Interactions and Pathways
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(CMV:kitlga-JRed) |
|
| 1 | (3) | |
| Tg(hsp70l:kitlga) |
|
| 1 | (5) | |
| Tg(hsp70l:kitlga,csf1a,NLS-CFP) |
|
| 1 | (2) | |
| Tg(hsp70l:kitlga,csf1b,NLS-CFP) |
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30I6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-106N21 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001018123 (1) | 819 nt | ||
| Genomic | GenBank:BX323796 (2) | 139583 nt | ||
| Polypeptide | UniProtKB:Q56JH6 (1) | 272 aa |
- Hui, J.C.M., Du, P., Webb, S.E., Liu, J.Y.H., Ngan, M.P., Lu, Z., Ng, H.S.H., Yang, L., Khalid, A., Liu, L., Li, Z., Deng, Y., Cui, D., Rudd, J.A. (2024) Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits. PLoS One. 19:e0314515e0314515
- Frantz, W.T., Iyengar, S., Neiswender, J., Cousineau, A., Maehr, R., Ceol, C.J. (2023) Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. eLIFE. 12:
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Kim, D., Koun, S., Kim, S.Y., Ha, Y.R., Choe, J.W., Jung, S.W., Hyun, J.J., Jung, Y.K., Koo, J.S., Yim, H.J., Lee, S.W. (2021) Prokinetic effects of diatrizoate meglumine (Gastrografin®) in a zebrafish for opioid-induced constipation model. Animal cells and systems. 25:264-271
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Oltova, J., Svoboda, O., Machonova, O., Svatonova, P., Traver, D., Kolar, M., Bartunek, P. (2020) Zebrafish Kit ligands cooperate with erythropoietin to promote erythroid cell expansion. Blood advances. 4:5915-5924
- Yu, G., Liu, X., Zhang, D., Wang, J., Ouyang, G., Chen, Z., Xiao, W. (2020) Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development (Cambridge, England). 147(18):
- Crespo, D., Assis, L.H.C., van de Kant, H.J.G., de Waard, S., Safian, D., Lemos, M.S., Bogerd, J., Schulz, R.W. (2019) Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens. Development (Cambridge, England). 146(21):
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