Gene

kitlga

ID
ZDB-GENE-070424-1
Name
kit ligand a
Symbol
kitlga Nomenclature History
Previous Names
  • kitla (1)
  • slk (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have cytokine activity and stem cell factor receptor binding activity. Involved in melanocyte differentiation. Predicted to localize to plasma membrane. Is expressed in several structures, including endocrine system; gut; integument; neural crest cell; and segmental plate. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kitlga Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 69 Alliance Deafness, autosomal dominant 69, unilateral or asymmetric 616697
familial progressive hyperpigmentation with or without hypopigmentation Alliance Hyperpigmentation with or without hypopigmentation 145250
[Skin/hair/eye pigmentation 7, blond/brown hair] 611664
Associated With kitlga Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR003452 Stem cell factor
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Stem cell factor
UniProtKB:F1Q6D8 88
UniProtKB:Q56JH6 272
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations