Genomic Feature
tx226
- ID
- ZDB-ALT-980203-1302
- Name
- tx226
- Synonyms
-
- AX26A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 36516517 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Trp>Stop at position 234 (1)
- Flanking Sequence
-
CAGATGGGCTCCGCTTTCTCAGATGCACCAATAAGGAACCGGCGCTCGGGCCCACAGGCCTTTAGACTCATGCAGCTTCACAACAATGCTGTTGGCAGACAGGTAAAGCCTCAACCACATGCTGGATTTCCACAGAAGACTGGCATCATTCACTGTAGACATAGCAGGGTTCCATTCAATTCATTCAGGTTGTCTCAACACAAATCTATTAGGTGACTTAACAATCTGAGTAGATTGAACATAAAACAATCGTTGTCCCAAACATAAAACAACAAGTTGTCCCAAAAAATCTTAAGAGTTGTGTTGATTAAGCTCATTTTACATAAGTAGCATGAACAGGTCACAGTAAATTAATAATGAAAATAGTAATTATTTTTTTGAGTGTTTCGATCAGTATCATGAATCTGTGTGTTCGTGTTTGTAAAGGTGCTTATGGACTCTCTAGAGATGAAGTGCAAATGTCATGGCGTTTCTGGCTCATGCTCTGTAAAGACCTGTTG
G/A AAGGGTCTTCAAGACATCAGCACCATCTCCGCCGACCTCAAGTCTAAATACCTGTCGGCCACCAAGGTGATTCCGCGTCAGATTGGCACACGCCGGCAGCTTGTGCCCCGAGAGATGGAGGTGAGGCCGGTTGGAGAGAATGAACTAGTCTACCTGGTCAGCTCACCGGATTACTGCACACAGAACGCCAAACAGGGGTCACTGGGGACCACAGACAGGTGAGATTGACACGCATCATCAATCAAGATTATTGATCACTGATGAGTTGAGAGGGAGCTATCAGTCTGTAATGAATGAGGGATTATCACTGATCCCACAGACGGGACAGAGCACAGGGTGAAAAGAGGCACATGAATGGAGTGGGTTAAACATTGTCAAGGCGCACAGGCATGAAAACTGATTCTTGAACACAAATGGCCTCAAATGTTGTTGTTTGACTTTTTGGCCAGTGTTAACGTACACCATCAGGGTCTTACAACAGGGTGTTCGTGGGGTCTTAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| wnt11f2tx226/tx226 | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | ||
| wnt11f2tx226/tx226 | Homozygous | ♀-/- ♂-/- | 9 figures  from 4 publications | 8 figures from 5 publications | |
| wnt11f2tx226/tx226 | Homozygous | Unknown | 10 figures from 6 publications | 11 figures from 4 publications | |
| wnt11f2tx226/+ | Heterozygous | Unknown | Fig. 1 from Gerdes et al., 2007 | ||
| wnt11f2tx226/+ (AB) | Heterozygous | Unknown | |||
| wnt11f2tx226/tx226 + MO4-antxr2a | Complex | Fig. S7 from Castanon et al., 2013 | |||
| wnt11f2tx226/+ + MO1-bbs1 | Complex | 2 figures from Gerdes et al., 2007 | Fig. 1 from Gerdes et al., 2007 | ||
| wnt11f2tx226/+ + MO1-bbs4 | Complex | Fig. 1 from Gerdes et al., 2007 | Fig. 1 from Gerdes et al., 2007 | ||
| wnt11f2tx226/tx226 + MO3-dkk1b | Complex | 2 figures from Caneparo et al., 2007 | |||
| wnt11f2tx226/tx226 + MO2-fzd2 + MO3-fzd2 | Complex | Fig. 5 from Kilian et al., 2003 | Fig. 5 from Kilian et al., 2003 |
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Supplemental Information
- Genotyping protocol
- None
- Carroll, S.H., Schafer, S., Kawasaki, K., Tsimbal, C., Jule, A.M., Hallett, S.A., Li, E., Liao, E.C. (2024) Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. eLIFE. 13:
- Petridou, N.I., Corominas-Murtra, B., Heisenberg, C.P., Hannezo, E. (2021) Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7):1914-1928.e19
- Schauer, A., Pinheiro, D., Hauschild, R., Heisenberg, C.P. (2020) Zebrafish embryonic explants undergo genetically encoded self-assembly. eLIFE. 9:
- Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
- Petridou, N.I., Grigolon, S., Salbreux, G., Hannezo, E., Heisenberg, C.P. (2018) Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. Nature cell biology. 21(2):169-178
- Young, T., Poobalan, Y., Tan, E.K., Tao, S., Ong, S., Wehner, P., Schwenty-Lara, J., Lim, C.Y., Sadasivam, A., Lovatt, M., Wang, S.T., Ali, Y., Borchers, A., Sampath, K., Dunn, N.R. (2014) The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development (Cambridge, England). 141:3505-16
- Castanon, I., Abrami, L., Holtzer, L., Heisenberg, C.P., van der Goot, F.G., and González-Gaitán, M. (2013) Anthrax toxin receptor 2a controls mitotic spindle positioning. Nature cell biology. 15(1):28-39
- Wiweger, M.I., Zhao, Z., van Merkesteyn, R.J., Roehl, H.H., and Hogendoornm, P.C. (2012) HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas. PLoS One. 7(1):e29734
- Oteiza, P., Köppen, M., Krieg, M., Pulgar, E., Farias, C., Melo, C., Preibisch, S., Müller, D., Tada, M., Hartel, S., Heisenberg, C.P., and Concha, M.L. (2010) Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development (Cambridge, England). 137(20):3459-3468
- Panáková, D., Werdich, A.A., and MacRae, C.A. (2010) Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 466(7308):874-878
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