Genomic Feature
tm79a
- ID
- ZDB-ALT-980203-1201
- Name
- tm79a
- Synonyms
-
- M079A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 6: 7266212 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 454 (1)
- Flanking Sequence
-
TGAAAAAAAACTATTTGACTTCAACTATATGTCCACATAGTCACCAACACGTCTCTCTGTGCACCGTCAGCTTCAGGAGGAGCTGTGTAAAGTGAGCTCGGCCGTGTCTGAAGGAATGGAGGAATCGCGACGGCAGGTGCAGGAACTGAGCCACAGACTGCAGGAGCAGCAGCAGATCATTACCTCCCAAAACAAGCAGGTCAGTCTTGGATGCCAGCACAGGAAGAGGCTCCATTGTTCAGGATATCCTGTATTAGCGCAGCGGCACGAGCTGAAGGAGTGTACGGGTGTGAACACATCCGCACATTTTGAGCAATTATCATTACGCTGATTATGTTGTCAGCTTGTCGTTTATGCGGGTTGTATTTTAAGTTTGAAGCAACAGCTTAGATAATGTGTTGCCGACTGCAGATTTTTGTTGTTGTTGTAACCAATAACATATGGGTTTGTTTATGTGACAGATGAAACAGATCTCGTCAAAGCCGCCAACAATAACAGTA
C/T AGCGCGAAGGTTTGTGGATTTTACAGTTTTAGTCAAAAATATCATATAAACATCGTATCTGAGCAAAACTGTCCCCATAGTGTAATAAAAACAGACTTTTTTTAAAGTAATTGTGTTTTTGTTTCAGGGGTTTCCACCCCTTCTCCTGAAACTAAAGCGAAGGTGGTGGTCAGTGGTGAGTTCATTTATTTTTGTGTTTTATTCCTTATTGTAGGATGTTGGGTAAAATATCATAGGTCCAGTTAAAGTTAAAATTATTCGCCCTCCTTTTAATTAATTTATTTTTTCATTTTAAGATATTTCACAAATTATGTTTAAGAGAGCAAGGAATTTTTCCACAGTATTTCCTATAATATTTTTTCTTATTTGTTTTATTTTGGCTAGAATAAAAGCAGTTTTAATTAATTTTTTTAACCATTTTAAAGTCAATATTATTAGCCCCTTAATCTAGTTATTTTTTATTGTCTACAGAACAAAGCATCATTATACAATGACTTTCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dzip1tm79a/tm79a | Homozygous | ♀+/- ♂+/- | 12 figures  from 8 publications | 2 figures from 2 publications | |
| dzip1tm79a/+ (AB) | Heterozygous | Unknown | |||
| dzip1fo10a/+; dzip1tm79a/+ | Complex | Fig. 1 from Lamont et al., 2010 |
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Supplemental Information
- Genotyping protocol
- None
- Mich, J.K., Payumo, A.Y., Rack, P.G., Chen, J.K. (2014) In vivo imaging of hedgehog pathway activation with a nuclear fluorescent reporter. PLoS One. 9:e103661
- Stooke-Vaughan, G.A., Huang, P., Hammond, K.L., Schier, A.F., and Whitfield, T.T. (2012) The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (Cambridge, England). 139(10):1777-1787
- Glazer, A., Wilkinson, A., Backer, C.B., Lapan, S., Gutzman, J.H., Cheeseman, I.M., and Reddien, P.W. (2010) The Zn Finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Developmental Biology. 337(1):148-156
- Lamont, R.E., Vu, W., Carter, A.D., Serluca, F.C., MacRae, C.A., and Childs, S.J. (2010) Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. Mechanisms of Development. 127(3-4):159-168
- Swindell, E.C., Zilinski, C.A., Hashimoto, R., Shah, R., Lane, M.E., and Jamrich, M. (2008) Regulation and function of foxe3 during early zebrafish development. Genesis (New York, N.Y. : 2000). 46(3):177-183
- Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K. (2006) A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. Developmental Biology. 297(1):1-13
- Sekimizu, K., Nishioka, N., Sasaki, H., Takeda, H., Karlstrom, R.O., and Kawakami, A. (2004) The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development (Cambridge, England). 131(11):2521-2532
- Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. (2004) iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes & Development. 18(13):1565-1576
- Chen, J.-N., van Eeden, F.J.M., Warren, K.S., Chin, A., Nüsslein-Volhard, C., Haffter, P., and Fishman, M.C. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development (Cambridge, England). 124(21):4373-4382
- Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8
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