Genomic Feature
to27c
- ID
- ZDB-ALT-980203-1171
- Name
- to27c
- Synonyms
-
- O27C (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 787729 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>G (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TTAACGTGTTTTCTTGCCTAAACAAAGCAAAAGTACAGAACACTTTCGTTTAAGGGCAAGGGGTGACCCCTGGTGGTTTGGCGGTATGGGTTGCATATAGGGAGGATCGGCTTTTTAATGTTTATTCCCACCCTTCAGAGAAAGACTGAAAATACTGGAGAAATCCAGGAAAATACCTTTACGGAATATTAGCGGGATAGAACTGTGAAATATGTGAGATTCCCGTGAAAAACAGGAGGGTTGATGGGTATGGTTTTAGTAGCCCTTTTTATGTAAAACAAGTCTCTGATGTCTCTAGAGTTGGTAGTGACGTTTTAGCTCAGAATAGCACACATAATATTTTCAAACTCTCTGAAACTCGAACTCTCTTTGATACTAATTGAGGCGATTTGGTGACTGTCTCTTTTAATGCAAATGAGATTGTGCTCTTGTCAGAAGAGGGCGGAGCTACTATTAAGCATCTATATGCAGTAGATGTAAAACAGCAGTGTGTGTGTTGT
G/A GGTGCTGGTCAGGTGTGCATGTGTGCTTCAGTGTGAGTGTGTGCTTCATGCTGCTGTCAGTCTATATCGCTCCACATTTATAATCCTCTTAGTCTATGCTGACATTATTTTCAGCAGCTCAAACACTCTAACAGCTAATAGACAGACGGCTGCTTCTCACTCAGGGCTGCTGTTTATGCTAATGAGATGGAGAGATGAACACTAGTGGGCGGGGCTTTCTCCTTCTGATGACATGAGAATGCCAATCAAAGTGTTTTATTTATCAAGTCTGATTAGAACCAACACAATTTATTAAGTTTTACCCCTTAAAGCTGAACAATTCCTATTGACTTCCTTAGTAGGAATGAAAAATACTATGGAAGTCAATGTCCGTTTTTTTTTTTTTTCCAGCATACTTCAGTATATCTTCATTTGTGTTCAACAGAGGAAAGAAGAAAGGGAAGGATGAGTAAATAGTGACAGATTCTTATTTTGGCGGAGGGGGGACTGTCTCTTTAAGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| myo18bto27c/to27c | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | ||
| myo18bto27c/to27c (AB) | Homozygous | ♀+/- ♂+/- | 5 figures from Gurung et al., 2017 | Fig. S5 from Gurung et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735
- Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19):8603-8615
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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