Genomic Feature
tr233
- ID
- ZDB-ALT-980203-1047
- Name
- tr233
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 13: 6077745 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>Stop (1)
- Flanking Sequence
-
TGAGTCCGTCTTGGCAAGTGCCGCCATTCTGGCAGGGATAGGTGGCACACTCGTCGATGTTGTCTTCGCAGTGCGTTCCTGTGAATCCCTCAGGACACTGGCAAAGATAGGAGTCCACAAGATCGAGACACTGAGCATCTGCGGATGAAGAAAGACAGAAGACATGAGATGATTGGTTTAAACACACTCTCATCTGCATTTCAGGCATTAAAGAGATAGTTCCCCCAAAAATGAAACCACAAAGGTTTGAGTTTTGTTCTGTTGATATTCTGAAGGATGTTGGAAACCACTGACATCCCTAGTAGGACAAACAAATACTTCAACAGAACAACAACAACCAAAAAAATTGAGTAAATGATTGCAGAAGTTTCATTTTTTTGGGTAAACTATCAATGTACAAAGGAAGCATTCAATGTACCATTCGAGCAAGGGTTGGAGCTGCAGTGATCGATCTTCTTCTCACAGTTGAATCCAGCATAACCCATCGGGCACTGGCAGAA
A/T TATCCTCCCTCTGGGTTGTCAGCACAGTGTCCACCATTGAAGCAGGGGCCGTCGGCACAAGTCATGGCACTCAGCTCGCAGTTTCTTCCGTAGAAACCAGGAGGACAAGTGCAGCTGTAGGTGTTTTCAAGATCCTGCCAAATCCAATGAACGAGCGAGTTAGAACATTAATAATAAAGTCAACTCATACGACACCTAAATTGCTTATCATATTTATTAAACAGAACAAAAACTTACAGTGCAACTTCCTCCATTTCTGCACGGGCTGCCGGAGCATTCGTTGACCTCAATCTCACAGCTGTCCCCGGTGAAGCCAGGTCTGCATGAGCAGGTGTAGCTTCCCTGGCCTGTGTTGGTGCAAGTGGCTCCATTCTGGCACGGTTTGTGATGTGTGCAGTAATTGAGATCTGCAAACAAAATAAAACATGTAGTTTAGTCAGCTAGAGTCAATGGGCACCTTTGAACCAACAACTTGATCAACTGCTCGGCTTACGACGCTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dldtr233/tr233 | Homozygous | ♀-/- ♂-/- | 2 figures  from Troll et al., 2018 | ||
| dldtr233/tr233 | Homozygous | Unknown | 3 figures from 3 publications | 13 figures from 12 publications | |
| dldtr233/tr233 | Homozygous | ♀+/- ♂+/- | 9 figures from 5 publications | 10 figures from 6 publications | |
| dldtr233/tr233 + MO1-dld | Complex | ||||
| dldtr233/tr233; s870Tg | Complex | Fig. 1 from Sampaio et al., 2014 | Fig. 1 from Sampaio et al., 2014 | ||
| dldtr233/+; dlahi781Tg/hi781Tg | Complex | 2 figures from Mahler et al., 2010 | 2 figures from Mahler et al., 2010 | ||
| dldtr233/tr233; dlahi781Tg/hi781Tg | Complex | 3 figures from Mahler et al., 2010 | 4 figures from Mahler et al., 2010 | ||
| dldtr233/tr233; dlahi781Tg/+ | Complex | 2 figures from Mahler et al., 2010 | 2 figures from Mahler et al., 2010 | ||
| dldtr233/tr233; dlankhspGFFDMC72AEt | Complex | Fig. 2 from Okigawa et al., 2014 | |||
| dldtr233/tr233 + MO3-dla | Complex | Fig. 4 from Schebesta et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- Jacobo, A., Dasgupta, A., Erzberger, A., Siletti, K., Hudspeth, A.J. (2019) Notch-Mediated Determination of Hair-Bundle Polarity in Mechanosensory Hair Cells of the Zebrafish Lateral Line. Current biology : CB. 29(21):3579-3587.e7
- Sharma, P., Saraswathy, V.M., Xiang, L., Fürthauer, M. (2019) Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis. Scientific Reports. 9:9958
- Keskin, S., Devakanmalai, G.S., Kwon, S.B., Vu, H.T., Hong, Q., Lee, Y.Y., Soltani, M., Singh, A., Ay, A., Özbudak, E.M. (2018) Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling. Cell Reports. 23:2175-2185.e4
- LLeras Forero, L., Narayanan, R., Huitema, L.F.A., VanBergen, M., Apschner, A., Peterson-Maduro, J., Logister, I., Valentin, G., Morelli, L.G., Oates, A., Schulte-Merker, S. (2018) Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLIFE. 7
- Troll, J.V., Hamilton, M.K., Abel, M.L., Ganz, J., Bates, J.M., Stephens, W.Z., Melancon, E., van der Vaart, M., Meijer, A.H., Distel, M., Eisen, J.S., Guillemin, K. (2018) Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development (Cambridge, England). 145(4)
- Pintado, P., Sampaio, P., Tavares, B., Montenegro-Johnson, T.D., Smith, D.J., Lopes, S.S. (2017) Dynamics of cilia length in left-right development. Royal Society open science. 4:161102
- Tavares, B., Jacinto, R., Sampaio, P., Pestana, S., Pinto, A., Vaz, A., Roxo-Rosa, M., Gardner, R., Lopes, T., Schilling, B., Henry, I., Saúde, L., Lopes, S.S. (2017) Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer.. eLIFE. 6
- Liao, B.K., Jörg, D.J., Oates, A.C. (2016) Faster embryonic segmentation through elevated Delta-Notch signalling. Nature communications. 7:11861
- Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206
- Sampaio, P., Ferreira, R.R., Guerrero, A., Pintado, P., Tavares, B., Amaro, J., Smith, A.A., Montenegro-Johnson, T., Smith, D.J., Lopes, S.S. (2014) Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality?. Developmental Cell. 29(6):716-28
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