Genomic Feature
zf4050
- ID
- ZDB-ALT-250320-9
- Name
- zf4050
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 17: 35361175 - 35361178 (GRCz11) (1) Details
- Nucleotide change
- TAGC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AAGAAAGAAAGAAAGAAAAAAAGAAGAAAACATCAATGTTAACATTAAAGTTTTTAACCTGACTTCGCCTAATCCATATGTTTTGGATTACGTAAATTAAAAATAATAAAAGTAGTGTATGCAAATTAGCACCTTATTTGCATTGGCTATTCAAAAAAGCTTGAAAGAGTTTGCAAATCATAATGTAATCATTCAGCTGCATGGGGAAATGGCTATAATTATAACGTATAGGTTATCTTAATATTAATTTGACTTGTTGTACCCTAATCACCTGCACTTTTAAGAGACAAGTTGTTTACCTGCTTCTTTCAGCAGTCTTAAGCCTCGCTTTGCTTCTTCAATAGGCAAGACGAAAGAAGTCTTCGCGGTGTGGAAACAAAAGCCGCATTTGTAATTGCACTGCCGGGTGAAATGGTAGTTTACACTGCTTGGAGTTGTGAACGGAGCTCTGGATCCCTCTTTCTGTTTACTGGTGCGACTCTCTGGGCGGCTGATCTTTC
TAGC/- AGGAGTTTGTTGCACATGTGCGCCAGAAACCTGCATGGAGAGCCATCTCAACAGCGCTAAAAAGAAACTTTGAACGTTCTTTACACAAAGCTGCATCAACAGTCTAGCAAAGCCAAGTTGGTTTGATGTCACCATGATGAAGATGTGTCGATTCTGAAGCCCGGAGAACACACGCCTCTTTTATACGGGACGGGGCCGGGCAGTGTCAAGTTGCCACTCTGATCAGTTTCTTTTCTTGCTCGGGGGGACGGAAAACGAAAGATAAACACTATCAGCTGTTATGCACGAGTTTCATTTCTCTTATAGACACCTGATGCATTTAATTTTCATTATAGGCTGCCGCTCCCATAAAGCATGCAGGCCATTTATAATATTATAGGCTTATGATTATATGAATTTACAATATTTGGTTTGTCTCAGCATTCTGAACAGTGAAATAGCCAACAACAACAATATAACAACAAAAACGATCATTATTATTATTATTATTATTTTTATTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rsad2zf4050/zf4050 (AB) | Homozygous | ♀-/- ♂-/- | Fig. 5 from Shanaka et al., 2022 | Fig. 6 from Shanaka et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Shanaka, K.A.S.N., Jung, S., Madushani, K.P., Kim, M.J., Lee, J. (2023) Viperin mutation is linked to immunity, immune cell dynamics, and metabolic alteration during VHSV infection in zebrafish. Frontiers in immunology. 14:13277491327749
- Shanaka, K.A.S.N., Jung, S., Madushani, K.P., Wijerathna, H.M.S.M., Neranjan Tharuka, M.D., Kim, M.J., Lee, J. (2022) Generation of viperin-knockout zebrafish by CRISPR/Cas9-mediated genome engineering and the effect of this mutation under VHSV infection. Fish & shellfish immunology. 131:672-681
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